ArticleGels (Basel, Switzerland)2025
Fast Wound Healing with a New Functional Hyaluronic Acid Dual Network Hydrogel.
Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Hyaluronic Acid-Based Biomaterials for Soft Tissue Repair and Wound Healing: Clinical Evidence and Emerging Applications.Gels (Basel, Switzerland) · 2026Review
- Preparation and Investigation ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Review of recent advances in chitosan- and hyaluronic-acid-based wound dressings: fabrication, application, and types.Frontiers in pharmacology · 2026Review
- Retrospective analysis of the clinical efficacy of topical hyaluronic acid in promoting skin recovery and reducing inflammatory reactions after fractional laser treatment.Frontiers in medicine · 2026Article
- Biocompatible Stimuli-Sensitive Natural Hydrogels: Recent Advances in Biomedical Applications.Gels (Basel, Switzerland) · 2025Review
- Intelligent Biosensors Based on Hyaluronic Acid Hydrogels for Monitoring Chronic Wound Healing with the Involvement of Artificial Intelligence.Biosensors · 2025Review
- Elysee Exosome Versus Cellbooster Lift in Oral Wound Healing.Plastic and reconstructive surgery. Global open · 2025Article
- Biological Models for Evaluating Hydrogel-Based Formulations in Wound Healing.Gels (Basel, Switzerland) · 2025Review
- Advances in Hydrogel-Based Delivery of RNA Drugs for Antitumor Therapy.Gels (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
As dressings for moist wound healing, hyaluronic acid hydrogels play a significant role in maintaining moisture and promoting wound healing. However, existing hydrogel dressings are inadequate in terms of slow gelation time, weak mechanical performance, and fast degradation, which increases the risk of secondary infections during treatment. Therefore, we developed a hyaluronic acid double network hydrogel (DNH). Compared to single-network hydrogels (hydrazone and Diels-Alder), DNH shows a short gelation time (25 s) and strong mechanical properties (Young's modulus = 82 kPa). These advantages enable DNH to immediately fill the irregular shape of the wound after gelation and remain intact after being squeezed. Swelling tests indicated that DNH had a suitable swelling ratio and maintained its structural integrity after swelling. We evaluated the use of DNH as a moist dressing for full-thickness wound healing in vivo. DNH-treated wounds healed faster, with enhanced blood vessel formation and macrophage polarization than gauze-treated wounds. These findings suggest that DNH not only accelerates wound healing but also improves tissue regeneration. Therefore, DNH may be a suitable moist dressing for wound healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.