Evidence map›Paper›PMID 40277677›Full record

ArticleGels (Basel, Switzerland)2025

Preparation of pH-Sensitive Poly (N-(2-Hydroxyethyl) Acrylamide-co-acrylic Acid) Hydrogels and Their Performance.

Qiang Liu, Ge Xi, Tao Wu, Peining Li, Peng Zhan, Na Liu, Zhiping Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qiang LiuSchool of Chemistry and Chemical Engineering, Central South University of Forestry and Technology, Changsha 410004, China.ORCID 0009-0008-7653-3424
Ge XiSchool of Chemistry and Chemical Engineering, Central South University of Forestry and Technology, Changsha 410004, China.
Tao WuSchool of Chemistry and Chemical Engineering, Central South University of Forestry and Technology, Changsha 410004, China.
Peining LiSchool of Chemistry and Chemical Engineering, Central South University of Forestry and Technology, Changsha 410004, China.
Peng ZhanSchool of Chemistry and Chemical Engineering, Central South University of Forestry and Technology, Changsha 410004, China.
Na LiuSchool of Chemistry and Chemical Engineering, Central South University of Forestry and Technology, Changsha 410004, China.
Zhiping WuSchool of Chemistry and Chemical Engineering, Central South University of Forestry and Technology, Changsha 410004, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug-loaded hydrogels are promising for modern medicine due to their physical modifiability. However, most hydrogels suffer from poor swelling, which limits their drug encapsulation and release capabilities. In this study, Poly (N-(2-hydroxyethyl) acrylamide-co-acrylic acid) (Poly (HEAA-co-AA)) hydrogels with high swelling properties are synthesized via free radical polymerization of neutralized acrylic monomers. The effects of the material ratio and acrylic acid neutralization degree on the swelling properties of hydrogels in water are investigated, and the swelling properties of hydrogels prepared with different monomer ratios in different pH buffer solutions are systematically studied. The results show that the swelling degree is sensitive to the monomer ratio and pH. The maximum equilibrium swelling degree of the hydrogels occurs at an HEAA to AA molar ratio of 2:2, with values of 11.36 g g

Indexed as

acrylic acidmechanical propertiesN-(2-hydroxyethyl) acrylamideN, N′-bis(acryloyl) cystaminepH sensitivity

Identifiers

PMID40277677
PMCPMC12027044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.