A Structural Optimization Framework for Biodegradable Magnesium Interference Screws.

Biodegradable magnesium alloys have garnered increasing attention in recent years, with magnesium alloy-based biomedical devices being clinically used. Unlike biologically inert metallic materials, magnesium-based medical devices degrade during service, resulting in a mechanical structure that evolves over time. However, there are currently few computer-aided engineering methods specifically tailored for magnesium-based medical devices. This paper introduces a structural optimization framework for Mg-1Ca interference screws, accounting for degradation using a continuum damage model (CDM). The Optimal Latin Hypercube Sampling (OLHS) technique was employed to sample within the design space. Pull-out strengths were used as the optimization objective, which were calculated through finite element analysis (FEA). Both Response Surface Methodology (RSM) and Kriging models were employed as surrogate models and optimized using the Sequential Quadratic Programming (SQP) algorithm. The results from the Kriging model were validated through FEA, and were found to be acceptable. The relationships between the design parameters, the rationale behind the methodology, and its limitations are discussed. Finally, a final design is proposed along with recommendations for interference screw design.