Evidence map›Paper›PMID 40277557›Full record

ReviewBiosensors2025

Single-Cell Endoscopy for Multifunctional Live-Cell Molecular Analysis.

Haoze Xue, Li Wang, Han Yao, Shuwei Shen, Xu Zhao, Chenxi Yuan, Luting Yu, Guoguang Chen, Jia Liu

Abstract readReview
In one paragraph

Review in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haoze XueSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
Li WangSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
Han YaoSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
Shuwei ShenSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
Xu ZhaoSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
Chenxi YuanSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
Luting YuSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
Guoguang ChenSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
Jia LiuSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.ORCID 0000-0002-7531-4616

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular analyses of individual cells with high resolution, specificity, and sensitivity can not only reveal cellular heterogeneity but also provide a better understanding of diseases and accelerate drug discoveries. Single-cell endoscopy is an advanced live-cell technique that relies on a smart endoscope that allows minimally invasive probing of the interiors of individual cells. Compared with other single-cell analysis techniques, single-cell endoscopy has shown great promise in applications such as flexible single-cell manipulation, ultrasensitive sensing, and precise intracellular delivery. In this review, we aim to map out the landscape of recent advances in single-cell endoscopy techniques by focusing on both fundamental considerations and significant progress over the past decade. Specifically, we summarize the predominant live-cell endoscopes, including their fabrication and characterization. Furthermore, a series of valuable intracellular molecular sensing events, such as nucleic acids, proteins, ions, etc., are introduced with a main emphasis on how single-cell endoscopy can solve these issues and what merits single-cell endoscopy can provide. Finally, we briefly outline the remaining challenges and directions for the future development of single-cell endoscopy techniques.

Indexed as

Biosensing TechniquesEndoscopySingle-Cell AnalysisAnimalsHumanshigh resolutionlive-cell techniquemolecular analysessingle-cell analysissingle-molecule sensitivity

Identifiers

PMID40277557
PMCPMC12024890

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.