ArticleBiosensors2025
Intra- and Inter-Regional Complexity in Multi-Channel Awake EEG Through Multivariate Multiscale Dispersion Entropy for Assessing Sleep Quality and Aging.
Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Entropy-Based Analysis of Olfactory EEG as a Candidate Biomarker for Early Mild Cognitive Impairment Detection: A Proof-of-Concept Study.Biosensors · 2026Article
- Electroencephalographic Biomarkers in Tinnitus: A Narrative Review of Current Approaches and Clinical Perspectives.Brain sciences · 2025Review
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Authors and funding
6 authors.
Funding
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Abstract
Aging and poor sleep quality are associated with altered brain dynamics, yet current electroencephalography (EEG) analyses often overlook regional complexity. This study addresses this gap by introducing a novel integration of intra- and inter-regional complexity analysis using multivariate multiscale dispersion entropy (mvMDE) from awake resting-state EEG for the first time. Moreover, assessing both intra- and inter-regional complexity provides a comprehensive perspective on the dynamic interplay between localized neural activity and its coordination across brain regions, which is essential for understanding the neural substrates of aging and sleep quality. Data from 58 participants-24 young adults (mean age = 24.7 ± 3.4) and 34 older adults (mean age = 72.9 ± 4.2)-were analyzed, with each age group further divided based on Pittsburgh Sleep Quality Index (PSQI) scores. To capture inter-regional complexity, mvMDE was applied to the most informative group of sensors, with one sensor selected from each brain region using four methods: highest average correlation, highest entropy, highest mutual information, and highest principal component loading. This targeted approach reduced computational cost and enhanced the effect sizes (ESs), particularly at large scale factors (e.g., 25) linked to delta-band activity, with the PCA-based method achieving the highest ESs (1.043 for sleep quality in older adults). Overall, we expect that both inter- and intra-regional complexity will play a pivotal role in elucidating neural mechanisms as captured by various physiological data modalities-such as EEG, magnetoencephalography, and magnetic resonance imaging-thereby offering promising insights for a range of biomedical applications.
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Registered trials
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