Evidence map›Paper›PMID 40277518›Full record

ArticleBiosensors2025

DNA-Engineered Coating for Protecting the Catalytic Activity of Platinum Nanozymes in Biological Systems.

Lei Ren, Xia Liu, Shuai Tang, Yue Wang, Miao Yang, Linjie Guo, Jiang Li, Kai Jiao, Lihua Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lei RenDivision of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.
Xia LiuInstitute of Materiobiology, College of Sciences, Shanghai University, Shanghai 200444, China.
Shuai TangInstitute of Materiobiology, College of Sciences, Shanghai University, Shanghai 200444, China.
Yue WangDivision of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.ORCID 0009-0009-4242-9693
Miao YangInstitute of Materiobiology, College of Sciences, Shanghai University, Shanghai 200444, China.
Linjie GuoInstitute of Materiobiology, College of Sciences, Shanghai University, Shanghai 200444, China.
Jiang LiInstitute of Materiobiology, College of Sciences, Shanghai University, Shanghai 200444, China.
Kai JiaoInstitute of Materiobiology, College of Sciences, Shanghai University, Shanghai 200444, China.
Lihua WangInstitute of Materiobiology, College of Sciences, Shanghai University, Shanghai 200444, China.

Funding

National Key R&D Program of China 2023YFB3208200National Natural Science Foundation of China 22325406, 22204100, 32301185, 22393931
6 · The paper itself

Abstract

Nanozymes, exemplified by metal nanoparticles, have shown promise in the fields of biological diagnostics and therapeutics. However, their practical application is often hindered by aggregation or deactivation in complex biological systems. Here, we develop a DNA-engineered nanozyme coating to preserve the peroxidase-like catalytic activity of platinum nanoparticles in complex biological environments. We employed thiol-modified single-stranded DNA to coat the platinum nanoparticles through metal-sulfur interaction. We found that the negatively charged DNA coating prevents the aggregation of platinum nanoparticles in high-salt environments. Moreover, the DNA coating functions as a molecular sieve, inhibiting non-specific protein adsorption while preserving substrate access to the catalytic interface, thus sustaining high peroxidase-like catalytic activity in serum. As a proof of concept, we demonstrate miRNA detection in serum samples with a detection limit of 1 fM. This approach offers a versatile strategy for molecular diagnostics of nanozymes in complex biological environments.

Indexed as

Biosensing TechniquesDNAMetal NanoparticlesPlatinumCatalysisHumansMicroRNAsDNAMicroRNAsPlatinumDNA coatingmiRNA detectionnanozymeplatinum nanoparticles

Identifiers

PMID40277518
PMCPMC12024773

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.