ArticleInternational journal of surgery (London, England)2025
Patient-reported outcomes by individuals with differentiated thyroid cancer who underwent minimal-access versus conventional open thyroidectomy: a real-world propensity score-matching study.
Article in International journal of surgery (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Longitudinal health-related quality of life after remote-access versus open thyroidectomy for thyroid cancer: a systematic review and meta-analysis.Journal of robotic surgery · 2026Pooled it
- [Application of domestic single-port robotic surgical system in thyroid cancer].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMinimal-access surgery has been widely used in differentiated thyroid cancer (DTC) management and its therapeutic effectiveness is well-proven. However, little is known about how minimal-access thyroidectomy affects patient-reported outcomes (PRO). MATERIALS AND
methodsIn this real-world cross-sectional study, 6221 patients with DTC who underwent minimal-access or conventional open thyroidectomy were included and required to fill out PRO questionnaires, including the Thyroid Cancer-Specific Quality of Life, the European Organisation for Research and Treatment of Cancer's Core Quality of Life Questionnaire, and Fear of Progression Questionnaire-Short Form. Of the 3586 patients who completed the questionnaires entirely, 915 and 2671 belonged to the minimal-access and open groups, respectively. To reduce bias and balance confounding factors, propensity score matching was performed, after which 1818 patients were equally divided between the two groups.
resultsCompared with the open group, the minimal-access group reported better PRO in terms of the THYCA-QOL summary score ( P < 0.001), neuromuscular ( P = 0.038), voice ( P < 0.001), concentration ( P = 0.044), sympathetic ( P = 0.002), throat/mouth ( P < 0.001), and scar ( P < 0.001), feeling chilly ( P < 0.001), and tingling hands/feet ( P = 0.002). Subgroup analysis demonstrated that minimal-access thyroidectomy can be optimal for most patients from the PRO perspective. Moreover, longitudinal PRO comparisons indicated that at ≤6 months postoperatively, the open group experienced more problems in neuromuscular, voice, sympathetic, throat/mouth, scar, feeling chilly, tingling hands/feet, headache, and lower global health status scores (all P < 0.05). However, except for voice, scar and tingling hands/feet, nearly all the differences disappeared after 7 months postoperatively. Intergroup comparisons suggested that the minimal-access group required less time to recover to a stable state.
conclusionsThe minimal-access group exhibited significantly superior postoperative PRO compared to the open group. Furthermore, the PRO trajectories of the two groups differed, with the minimal-access group demonstrating a considerably shorter recovery time. If better PRO is desired, minimal-access thyroidectomy may be preferred.
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