Evidence map›Paper›PMID 40277365›Full record

ArticleApplied and environmental microbiology2025

Elucidation of novel turnagainolides and their biosynthetic gene cluster in

Peng Li, Shuang Han, Min Wang, Xuejiao Zhang, Shuai Zhi, Meiling Jin, Jouni Jokela, Shan He, Liwei Liu

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Bioprospecting Indoor Bacteria Producing Bioactive Metabolites.Environmental microbiology reports · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peng Li *Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Health Science Center, Ningbo University, Ningbo, Zhejiang, China.
Shuang Han *College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
Min WangCollege of New Materials and Chemical Engineering, Beijing Institute of Petrochemical Technology, Beijing, China.
Xuejiao ZhangNational-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China, Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management, Institute of Eco-environmental and Soil Sciences, Guangdong Academy of Sciences, Shenyang, China.
Shuai ZhiSchool of Public Health, Ningbo University, Ningbo, Zhejiang, China.
Meiling JinChinese Academy of Sciences (CAS) Key Laboratory of Quantitative Engineering Biology, Chinese Academy of Sciences Shenzhen Institute of Advanced Technology, Shenzhen, Guangdong, China.
Jouni JokelaDepartment of Microbiology, University of Helsinki, Helsinki, Finland.
Shan HeLi Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Health Science Center, Ningbo University, Ningbo, Zhejiang, China.ORCID 0000-0002-0196-7278
Liwei LiuLi Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Health Science Center, Ningbo University, Ningbo, Zhejiang, China.ORCID 0000-0002-0578-1091

Funding

Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Development Fund (Li Dak Sum Yip Yio Chin Kenneth Li. Marine Biopharmaceutical Development Fund)MOST | National Natural Science Foundation of China (NSFC) 42176101National 111 Project of China D16013National Key Research and Development Program of China 2018YFA0903004National Natural Science Foundation of China 31600016Ningbo Key Science and Technology Development program 2021Z046Startup Foundation of Ningbo University 422010882, 422110473, 422207513
6 · The paper itself

Abstract

Turnagainolides represent a unique class of cyclic depsipeptides characterized by the presence of a rare ( IMPORTANCE: Microbial natural products represent an invaluable resource in drug discovery, providing a vast reservoir of structurally and functionally diverse compounds with promising therapeutic potential. A comprehensive understanding of natural product biosynthesis not only deepens our knowledge of their chemical complexity but also drives advancements in chemical synthesis and metabolic engineering, paving the way for the generation of novel bioactive compounds. In this study, we report that a marine axenic culture of

Indexed as

Bacillus subtilisBiosynthetic PathwaysDepsipeptidesMultigene FamilyAnti-Bacterial AgentsBacterial ProteinsPhylogenyAnti-Bacterial AgentsBacterial ProteinsDepsipeptidesBacillusbioactivitybiosynthesisdepsipeptidesecondary metaboliteturnagainolide

Identifiers

PMID40277365
PMCPMC12094020

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.