Evidence map›Paper›PMID 40277342›Full record

ArticleStatistics in medicine2025

A Joint Model for (Un)Bounded Longitudinal Markers, Competing Risks, and Recurrent Events Using Patient Registry Data.

Pedro Miranda Afonso, Dimitris Rizopoulos, Anushka K Palipana, Emrah Gecili, Cole Brokamp, John P Clancy, Rhonda D Szczesniak, Eleni-Rosalina Andrinopoulou

Abstract read
In one paragraph

Article in Statistics in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pedro Miranda AfonsoDepartment of Biostatistics, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0001-6708-9597
Dimitris RizopoulosDepartment of Biostatistics, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0001-9397-0900
Anushka K PalipanaDuke University School of Nursing, Durham, NC, USA.
Emrah GeciliDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Cole BrokampDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
John P ClancyCystic Fibrosis Foundation, Bethesda, MD, USA.
Rhonda D SzczesniakDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID https://orcid.org/0000-0003-0705-715X
Eleni-Rosalina AndrinopoulouDepartment of Biostatistics, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0002-5372-4163

Funding

R01- Mapping environmental contributions to rapid lung disease progression in cystic fibrosisR01HL141286 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI SZCZESNIAK, RHONDA · 2019 to 2023
$2.3M
NIH HHS R01 HL141286
6 · The paper itself

Abstract

Joint models for longitudinal and survival data have become a popular framework for studying the association between repeatedly measured biomarkers and clinical events. Nevertheless, addressing complex survival data structures, especially handling both recurrent and competing event times within a single model, remains a challenge. This causes important information to be disregarded. Moreover, existing frameworks rely on a Gaussian distribution for continuous markers, which may be unsuitable for bounded biomarkers, resulting in biased estimates of associations. To address these limitations, we propose a Bayesian shared-parameter joint model that simultaneously accommodates multiple (possibly bounded) longitudinal markers, a recurrent event process, and competing risks. We use the beta distribution to model responses bounded within any interval

Indexed as

BiomarkersModels, StatisticalRegistriesBayes TheoremBody Mass IndexComputer SimulationCystic FibrosisHumansLongitudinal StudiesRecurrenceSurvival AnalysisBiomarkersbounded outcomescompeting riskscystic fibrosisjoint modelmultivariate longitudinal datarecurrent events

Identifiers

PMID40277342
PMCPMC12023843

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.