Evidence map›Paper›PMID 40277335›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Aqueous Self-Assembly of Cylindrical and Tapered Bottlebrush Block Copolymers.

Clark Vu, Narjess Abu Amara, Mohammed Alaboalirat, Einat Nativ-Roth, Ran Zalk, Wellington Leite, Jan-Michael Carrillo, Ronit Bitton, John B Matson

Abstract read
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In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Aqueous Self-Assembly of Cylindrical and Tapered Bottlebrush Block Copolymers.Angewandte Chemie (International ed. in English) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Clark Vu *Department of Chemistry, Virginia Tech, Blacksburg, VA, 24061, USA.
Narjess Abu Amara *Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Mohammed AlaboaliratMacromolecules Innovation Institute, Virginia Tech, Blacksburg, VA, 24061, USA.
Einat Nativ-RothIlse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Ran ZalkIlse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Wellington LeiteNeutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, USA.
Jan-Michael CarrilloCenter for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, USA.
Ronit BittonDepartment of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
John B MatsonDepartment of Chemistry, Virginia Tech, Blacksburg, VA, 24061, USA.

Funding

Guzik FoundationOffice of Science of the U.S. Department of Energy DE-AC05-00OR22725US-Israel Binational Science Foundation NSF-BSF 2020715US National Science Foundation DMR-2104602
6 · The paper itself

Abstract

The self-assembly of amphiphilic bottlebrush block copolymers (BCPs), featuring backbones densely grafted with two types of side chains, is less well understood compared to linear BCPs. In particular, the solution self-assembly of tapered bottlebrush BCPs-cone-shaped BCPs with hydrophilic or hydrophobic tips-remains unexplored. This study investigates eight tapered and four cylindrical bottlebrush BCPs with varied ratios of hydrophobic polystyrene (PS) and hydrophilic poly(acrylic acid) (PAA) side chains, synthesized via sequential addition of macromonomers using ring-opening metathesis polymerization (SAM-ROMP). Self-assembled nanostructures formed in water were analyzed using cryogenic transmission electron microscopy, small-angle neutron scattering, and dynamic light scattering. Most BCPs generated multiple nanostructures with surface protrusions, including spherical micelles, cylindrical micelles, and vesicles, alongside transitional forms like ellipsoids and semi-vesicles. Coarse-grained molecular dynamics simulations supported the experimental findings, which revealed two distinct self-assembly pathways. The first involved micelle fusion, producing elliptical and cylindrical aggregates, sometimes forming Y-junctions. The second pathway featured micelle maturation into semivesicles, which developed into vesicles or large compound vesicles. This work provides the first experimental evidence of vesicle formation via semivesicles in bottlebrush BCPs and demonstrates the significant influence of cone directionality on self-assembly behavior in these cone-shaped polymeric amphiphiles.

Indexed as

Atom‐transfer radical polymerizationCryo‐electron tomographyGrubbs third generation catalystSemi‐vesiclesSize exclusion chromatography with multi‐angle light scattering

Identifiers

PMID40277335
PMCPMC12124441

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.