Trial reportAnnals of African medicine2025
To Compare the Efficacy of Preoperative Oral 50 g of Maltodextrin versus 50 g of Glucose in Reducing Postoperative Nausea and Vomiting, in Patients Undergoing Laparoscopic Cholecystectomy under General Anesthesia: A Randomized Controlled Double-blind Study.
Trial report in Annals of African medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
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Abstract
backgroundPostoperative nausea and vomiting (PONV) is the second most common complaint following general anesthesia. Despite multimodal strategies to reduce PONV, it still occurs in 20%-30% of patients. Major surgery induces metabolic changes, resulting in insulin resistance. Oral carbohydrate (CHO) loading 2 h before surgery modifies insulin resistance and improves postoperative patient comfort including reduction of PONV. PATIENTS AND
methodsThe present study was a prospective, randomized controlled double-blinded study. 105 patients aged 18-60 years undergoing laparoscopic cholecystectomy under general anesthesia were randomized into three groups: M (50 mg of oral maltodextrin in 100 ml water), G (50 mg of oral glucose in 100 ml water), and C (100 ml of plain water). Each group received the samples 2 h before induction and underwent routine induction and intervention. Their vital parameters were monitored perioperatively and were also evaluated for PONV and perioperative comfort levels.
resultsStatistically significant relationship between the groups and postoperative comfort score (χ 2 = 34.56, P ≤ 0.001, Cramé's V = 0.41). Analysis of variance test showed difference between the different groups and postextubation General Random Blood Sugar (GRBS) ( F = 16.11, P ≤ 0.001). No significant difference was seen among the three groups in preoperative comfort scores (χ 2 = 0.72, P = 0.699, Cramé's V = 0.08) and preoperative GRBS ( P = 0.055).
conclusionIt was concluded that the oral intake of CHO drink 2 h before surgery improves the comfort of patients by reducing preoperative hunger and thirst along with smaller postoperative glucose spike in the maltodextrin group.
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