ArticleTransfusion2025
Insulin resistance, overweight, and obesity in apheresis donors: A call to reevaluate their eligibility-A prospective cohort study.
Article in Transfusion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
15 authors.
Funding
Abstract
backgroundApheresis procedures and the infusion of acid-citrate-dextrose induce metabolic alterations that may influence glucose metabolism. Although insulin resistance (IR), overweight, and obesity are not exclusion criteria for blood donation, their impact during apheresis procedure and on post-donation metabolic responses remains insufficiently characterized. STUDY DESIGN AND
methodsA prospective cohort study was conducted with plateletpheresis donors approved by the IRB. Blood samples were collected at three time points: pre-donation, immediately post-donation, and 90 min post-meal for biochemical and hormonal profiling. Donors consumed a supervised post-donation meal (415 kcal) within 30 min. IR was assessed using the Homeostasis Model Assessment (HOMA-IR), while overweight and obesity were evaluated through body mass index (BMI). Multiple linear regression models were adjusted based on directed acyclic graphs.
resultsA total of 108 plateletpheresis donors were included. Post-donation, all donors exhibited significant increases in glucose, insulin, and C-peptide levels, with changes up to threefold higher in donors with IR, overweight, or obesity (p < .001). Mineral chelation occurred universally, independent of HOMA-IR or BMI status. Donors without IR or those with normal weight achieved baseline glucose levels following the post-donation meal. Linear regression analysis revealed that post-donation glucose changes were comparable to those induced by the 415-kcal meal.
conclusionDonors with IR, overweight, or obesity are at risk of experiencing disruptions in glucose and insulin levels, for which recovery times remain unknown. Therefore, they require assessment and education regarding potential metabolic alterations associated with the apheresis procedure.
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