Evidence map›Paper›PMID 40277240›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2025

Protein-Like Polymers Targeting Keap1/Nrf2 as Therapeutics for Myocardial Infarction.

Joshua M Mesfin, Kendal P Carrow, Alexander Chen, Madeline P Hopps, JoJo J Holm, Quincy P Lyons, Michael B Nguyen, Jervaughn D Hunter, Assa Magassa, Elyse G Wong and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Joshua M MesfinShu Chien-Gene Lay Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, CA, 92037, USA.ORCID https://orcid.org/0000-0003-1022-8175
Kendal P CarrowMedical Scientist Training Program, Department of Biomedical Engineering, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.ORCID https://orcid.org/0000-0002-3996-3352
Alexander ChenProgram in Materials Science and Engineering, Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, CA, 92037, USA.
Madeline P HoppsDepartment of Chemistry, International Institute for Nanotechnology, Simpson-Querrey Institute, Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, 60208, USA.ORCID https://orcid.org/0000-0002-0531-8582
JoJo J HolmDepartment of Chemistry, International Institute for Nanotechnology, Simpson-Querrey Institute, Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, 60208, USA.
Quincy P LyonsShu Chien-Gene Lay Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, CA, 92037, USA.
Michael B NguyenShu Chien-Gene Lay Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, CA, 92037, USA.
Jervaughn D HunterShu Chien-Gene Lay Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, CA, 92037, USA.
Assa MagassaDepartment of Chemistry, Department of Materials Science & Engineering, Department of Pharmacology, International Institute for Nanotechnology, Simpson-Querrey Institute, Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, 60208, USA.ORCID https://orcid.org/0000-0001-6082-0324
Elyse G WongShu Chien-Gene Lay Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, CA, 92037, USA.
Kate ReimoldShu Chien-Gene Lay Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, CA, 92037, USA.
Sriya N PaletiShu Chien-Gene Lay Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, CA, 92037, USA.
Emily GardnerShu Chien-Gene Lay Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, CA, 92037, USA.
Matthew P ThompsonDepartment of Chemistry, International Institute for Nanotechnology, Simpson-Querrey Institute, Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, 60208, USA.
Colin G LuoShu Chien-Gene Lay Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, CA, 92037, USA.
Xiaoyu ZhangDepartment of Chemistry, Department of Materials Science & Engineering, Department of Pharmacology, International Institute for Nanotechnology, Simpson-Querrey Institute, Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, 60208, USA.
Karen L ChristmanShu Chien-Gene Lay Department of Bioengineering, Program in Materials Science and Engineering, Sanford Consortium for Regenerative Medicine, Sanford Stem Cell Institute, University of California San Diego, La Jolla, CA, 92037, USA.ORCID https://orcid.org/0000-0002-6179-898X
Nathan C GianneschiDepartment of Biomedical Engineering, Department of Chemistry, Department of Materials Science & Engineering, Department of Pharmacology, International Institute for Nanotechnology, Simpson-Querrey Institute, Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, 60208, USA.ORCID https://orcid.org/0000-0001-9945-5475

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1M
Training in Multi-Scale Analysis of Biological Structure and FunctionT32EB009380 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrew D. McCulloch, Padmini Rangamani · 2009 to 2026
$4.8M
MMP responsive polymeric materials for treating acute myocardial infarctionR01HL139001 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Karen L Christman, Nathan Claude Gianneschi · 2017 to 2026
$3.9M
Integrative Bioengineering of Heart, Vessels, and BloodT32HL105373 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHIEN, SHU, INTAGLIETTA, MARCOS · 2010 to 2019
$3.6M
Chemistry of Life Processes Predoctoral Training ProgramT32GM149439 · NIGMS · NORTHWESTERN UNIVERSITY · PI NEIL L KELLEHER · 2023 to 2026
$1.6M
Training in Bioengineering Research and Technology Development in Cardiovascular in Cardiopulmonary Health and DiseaseT32HL160507 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Karen L Christman, Andrew D. McCulloch · 2022 to 2026
$1.6M
Discovery of small molecule-mediated protein degradation pathways in human cancerR00CA248715 · NCI · NORTHWESTERN UNIVERSITY · PI ZHANG, XIAOYU · 2022 to 2024
$747k
Discovery of small molecule-mediated protein degradation pathways in human cancerK99CA248715 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI ZHANG, XIAOYU · 2020 to 2021
$247k
Development of Protein Like Polymer Therapeutics for Modulating the Nrf2/Keap1 Protein Protein Interaction in Neurodegenerative DiseasesF30AG076317 · NIA · NORTHWESTERN UNIVERSITY · PI CARROW, KENDAL PAIGE · 2022 to 2025
$212k
Investigation of a Right Ventricle Based Decellularized Extracellular Matrix Hydrogel and Cardiac Progenitor Cells as a Treatment for Right Ventricular Heart FailureF31HL158212 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HUNTER, JERVAUGHN D · 2022 to 2023
$63k
AHA post-doctoral fellowship 24POST1242447AHA pre-doctoral fellowship 23PRE1023221AHA pre-doctoral fellowship 24PRE1180449Basic Research Laboratory R00CA248715Damon Runyon Cancer Research Foundation DFS-53-22Lurie Cancer Center P30CA060553National Institute of Heart, Lung, and Blood F31HL158212NCI NIH HHS K99 CA248715NCI NIH HHS P30 CA060553NCI NIH HHS R00 CA248715NHLBI NIH HHS F31 HL158212NHLBI NIH HHS R01 HL139001NHLBI NIH HHS T32 HL007444NHLBI NIH HHS T32 HL105373NHLBI NIH HHS T32 HL160507NIA NIH HHS 1F30AG076317-01A1NIA NIH HHS F30 AG076317NIBIB NIH HHS T32 EB009380NIGMS NIH HHS T32 GM149439NIH T32 Training T32EB009380NIH T32 Training T32HL007444NIH T32 Training T32HL105373Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource NSF ECCS-2025633
6 · The paper itself

Abstract

Myocardial infarction (MI) results in oxidative stress to the myocardium and frequently leads to heart failure (HF). There is an unmet clinical need to develop therapeutics that address the inflammatory stress response and prevent negative left ventricular remodeling. Here, the Keap1/Nrf2 protein-protein interaction is specifically targeted, as Nrf2 activation is known to mitigate the inflammatory response following MI. This is achieved using a Nrf2-mimetic protein-like polymer (PLP) to inhibit the Keap1-Nrf2 interaction. The PLP platform technology provides stability in vivo, potent intracellular bioactivity, and multivalency leading to high avidity Keap1 binding. In vitro and in vivo assays to probe cellular activity and MI therapeutic utility are employed. These Keap1-inhibiting PLPs (Keap1i-PLPs) impart cytoprotection from oxidative stress via Nrf2 activation at sub-nanomolar concentrations in primary cardiomyocytes. Single-digit mg kg

Indexed as

Kelch-Like ECH-Associated Protein 1Myocardial InfarctionNF-E2-Related Factor 2PolymersAnimalsHumansMaleMyocytes, CardiacOxidative StressRatsRats, Sprague-DawleyKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2Polymersbiomaterialdrug deliverymyocardial infarctionpolymers

Identifiers

PMID40277240
PMCPMC12243722

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.