ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025
Functional 3D Human Neuron-Glioblastoma Model Reveals Cellular Interactions Enabling Drug Safety Assessments.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Emerging biomimetic biopolymer-based composites: advancing accessible and sustainable neural disease models and therapeutics.Frontiers in bioengineering and biotechnology · 2025Review
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Authors and funding
8 authors.
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Abstract
Glioblastoma (GB) cells actively interact with the central nervous system (CNS) tumor microenvironment (TME). These interactions, particularly with neurons, require a better understanding. 3D tumor models replicating the human TME are needed to unravel pathological processes and to test novel treatments for efficacy and safety. We developed a novel 3D human coculture model for studying neuron-GB interactions. The model revealed both structural and functional interactions between cell types. Paracrine communication in the coculture model favored a tumor-supportive environment. Notably, cell-specific calcium signaling characteristics differed in cocultures compared to monocultures, highlighting the impact of interactions on cellular functionality in TME. The safety of a clinically used treatment, temozolomide, was tested in the 3D coculture model, and it selectively inhibited GB invasion while preserving neurons' morphology and functionality. The established model provides a tool for dissecting the interactions within the TME and testing the efficacy and safety of novel treatments.
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