Evidence map›Paper›PMID 40277121›Full record

ReviewCurrent medicinal chemistry2025

Anticancer Efficacy of Gingerol in Breast Cancer: Chemoprevention, Drug Synergism, and Nano-Formulations.

Pratibha Pandey, Sorabh Lakhanpal, Ashok Kumar Bishoyi, Subbulakshmi Ganesan, Mandeep Kaur, M Ravi Kumar, Mithilesh Singh, Renu Arya, Ajay Singh, Seema Ramniwas and 2 more

Abstract readReview
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In one paragraph

Review in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Pratibha PandeyCentre for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, India.
Sorabh LakhanpalSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
Ashok Kumar BishoyiDepartment of Microbiology, Marwadi University Research Center, Faculty of Science, Marwadi University, Rajkot, 360003, Gujarat, India.
Subbulakshmi GanesanDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India.
Mandeep KaurDepartment of Sciences, Vivekananda Global University, Jaipur, Rajasthan, 303012, India.
M Ravi KumarDepartment of Basic Science & Humanities, Raghu Engineering College, Visakhapatnam, India.
Mithilesh SinghDepartment of Pharmaceutical Chemistry, NIMS Institute of Pharmacy, NIMS University Rajasthan, Jaipur, India.
Renu AryaChandigarh Pharmacy College, Chandigarh Group of Colleges-Jhanjeri, Mohali, 140307, Punjab, India.
Ajay SinghSchool of Applied and Life Sciences, Uttaranchal University Dehradun, Dehradun, India.
Seema RamniwasUniversity Centre of Research and Development, University institute of Biotechnology, Chandigarh University Gharuan, Mohali, Punjab, India.
Meenakshi VermaUniversity Centre of Research and Development, University institute of Biotechnology, Chandigarh University Gharuan, Mohali, Punjab, India.
Fahad KhanCenter for Global Health Research Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Chennai, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is the most prevalent type of carcinoma among women worldwide and is the primary cause of cancer-related mortality. It is one of the most challenging cancers to manage and constitutes a significant proportion of cancer-related fatalities. The rising incidence of breast cancer necessitates the pursuit of more effective treatments. Due to the association of most chemotherapeutic medications with drug resistance, cancer recurrence, and adverse effects, researchers are exploring more effective alternatives, such as natural chemicals for the treatment and prevention of breast cancer. Chemoprevention using chemicals derived from plants has become a viable and accessible method for managing and controlling cancer. Among the numerous phytochemicals exhibiting an extensive range of biochemical and pharmacologic properties, gingerols have been documented to be efficacious in inhibiting the transformation, hyperproliferation, and inflammatory mechanisms that commence and foster carcinogenesis, along with the subsequent stages of carcinogenesis, angiogenesis, and metastasis. The chemotherapeutic potential of gingerol has been shown in several in vitro and in vivo studies. Clinical research has also documented the effectiveness of gingerol in cancer management. This review seeks to explore the pharmacological effects and mechanisms of gingerol with a primary emphasis on breast cancer therapy. This study aimed to highlight gingerol potential in addressing breast cancer and to inform future research pathways for the development of natural product-derived therapies.

Indexed as

Antineoplastic AgentsAntineoplastic Agents, PhytogenicBreast NeoplasmsCatecholsFatty AlcoholsNanoparticlesAnimalsDrug SynergismFemaleHumansAntineoplastic AgentsAntineoplastic Agents, PhytogenicCatecholsFatty Alcoholsgingerolbreast cancerchemopreventionGingerolnanoformulationphytochemicals.synergism

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.