ArticleJournal of cosmetic dermatology2025
Effective Skin Rejuvenation by a Novel Antioxidant Biostimulating Treatment.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Authors and funding
4 authors.
Funding
Abstract
backgroundFacial skin aging is a cumulative result of both intrinsic and extrinsic stressors. Chemical peels are commonly performed noninvasive skin rejuvenation procedures targeting these stressors. Innovation in chemical peels has remained limited, creating an opportunity for the industry to evolve with next-generation technology.
aimsA novel topical antioxidant biostimulating treatment (ABT) was developed that utilizes a typical chemoexfoliation base as a vehicle to deliver a unique blend of antioxidant biostimulating acidic phytocompounds (ABAP). It was hypothesized that controlled delivery of ABAP could occur through a typical AHA/BHA chemical peel vehicle. These ABAPs, such as asiatic, ursolic, madecassic, and oleanolic acids, are known for skin rejuvenation in the papillary dermis. PATIENTS/
methodsThe ABT was tested in both ex vivo and in vivo settings to elucidate its mechanism of action and determine its efficacy and safety on 32 female subjects aged 38-60 years with Fitzpatrick skin types I-V.
resultsThe ABT upregulated elastin and collagen after superficial wounding of the skin by over 25% when compared to untreated or vehicle controls. Clinical evaluation by an expert grader demonstrated that the ABT significantly improved fine lines, wrinkles, tactile laxity, and overall appearance after three ABT sessions. Clinical photography demonstrated an improvement in fine lines, wrinkles, skin smoothness, laxity, radiance, and overall appearance.
conclusionsThe ABT developed with ABAP technology was efficacious in improving facial skin aging for skin rejuvenation and safe for all skin tones.
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