ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia.
Abstract readComparative StudyMulticenter Study
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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Diagnosis of Frontotemporal Dementia in Individuals With Late-Onset Behavioral Changes: Importance of Genetic Counseling.Neurology. Genetics · 2026Article
- Proteomic analysis in Alzheimer's disease and other dementias: a focus on sex-specific differences.Alzheimer's research & therapy · 2026Article
- Exploring sex differences in bvFTD through clinician insights.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Sex differences for clinical presentations and co-pathologies in four-repeat tauopathies.Biology of sex differences · 2026Article
- Behavioral Variant Frontotemporal Dementia in the Context of Progressive Apraxia of Speech: A Clinico-Neuroimaging Case-Control Study.Brain sciences · 2025Article
- Sex differences in frontotemporal dementia.Nature reviews. Neurology · 2025Article
- Twenty years of therapeutic development in tauopathy mouse models: a scoping review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Glymphatic activity in behavioral variant frontotemporal dementia: Link with vascular function and astrocytic activation.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Sex differences in the clinical manifestation of autosomal dominant frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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Authors and funding
75 authors.
Xulin LiuKrembil Research Institute, University Health Network, Toronto, Canada.
Sterre C M de BoerAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, Amsterdam, the Netherlands.
Kasey CortezKrembil Research Institute, University Health Network, Toronto, Canada.
Jackie M PoosDepartment of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Ignacio Illán-GalaSant Pau Memory Unit, Department of Neurology, Biomedical Research Institute Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Hilary HeuerMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, Sandler Neurosciences Center, San Francisco, San Francisco, USA.
Leah K ForsbergDepartment of Neurology, Mayo Clinic, Rochester, USA.
Kaitlin CasalettoMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, Sandler Neurosciences Center, San Francisco, San Francisco, USA.
Molly MemelMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, Sandler Neurosciences Center, San Francisco, San Francisco, USA.
Brian S ApplebyDepartment of Neurology, Case Western Reserve University, Cleveland, USA.
Sami BarmadaUniversity of Michigan, Ann Arbor, USA.
Andrea BozokiUniversity of North Carolina, Chapel Hill, USA.
David ClarkIndiana University, Indianapolis, USA.
Yann CobigoMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, Sandler Neurosciences Center, San Francisco, San Francisco, USA.
Ryan DarbyVanderbilt University, Nashville, USA.
Bradford C DickersonDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA.
Kimiko Domoto-ReillyDepartment of Neurology, University of Washington, Seattle, USA.
Douglas R GalaskoUniversity of California, San Diego, La Jolla, USA.
Daniel H GeschwindDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, USA.
Nupur GhoshalDepartments of Neurology and Psychiatry, Washington University School of Medicine in St Louis, St. Louis, USA.
Neill R Graff-RadfordMayo Clinic, Jacksonville, USA.
Ian M GrantDepartment of Psychiatry and Behavioral Sciences, Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern Feinberg School of Medicine, Chicago, USA.
Ging-Yuek Robin HsiungUniversity of British Columbia, 2329 West Mall, Vancouver, Canada.
Lawrence S HonigNeurology Department and Taub Institute, Columbia University Irving Medical Center, New York, USA.
Edward D HueyDepartment of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, USA.
David IrwinPerelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Kejal KantarciDepartment of Neurology, Mayo Clinic, Rochester, USA.
Gabriel C LégerUniversity of California, San Diego, La Jolla, USA.
Irene LitvanUniversity of California, San Diego, La Jolla, USA.
Ian R MackenzieDepartment of Pathology, University of British Columbia, Vancouver, Canada.
Joseph C MasdeuNantz National Alzheimer Center, Houston Methodist, Houston, USA.
Mario F MendezDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, USA.
Chiadi U OnyikeDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, USA.
Belen PascualNantz National Alzheimer Center, Houston Methodist, Houston, USA.
Peter PressmanUniversity of Colorado Denver, Aurora, USA.
Ece BayramUniversity of Colorado Denver, Aurora, USA.
Eliana Marisa RamosDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, USA.
Erik D RobersonDepartment of Neurology, University of Alabama at Birmingham, Sparks Center, Birmingham, USA.
Emily RogalskiDepartment of Neurology, Healthy Aging & Alzheimer's Care Center, University of Chicago, Chicago, USA.
Arabella BouziguesDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
Lucy L RussellDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
Phoebe H FosterDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
Eve Ferry-BolderDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
Mario MasellisSunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Canada.
John van SwietenDepartment of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Lize JiskootDepartment of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Harro SeelaarDepartment of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Raquel Sanchez-ValleAlzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Barcelona, Spain.
Robert LaforceClinique Interdisciplinaire de Mémoire, Département des Sciences Neurologiques, CHU de Québec, and Faculté de Médecine, Université Laval, Quebec, Canada.
Caroline GraffKarolinska Institute, Department NVS, Centre for Alzheimer Research, Division of Neurogenetics, Stockholm, Sweden.
Daniela GalimbertiFondazione IRCCS Ospedale Policlinico, Milano, Italy.
Rik VandenbergheLaboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium.
Alexandre de MendonçaFaculty of Medicine, University of Lisbon, Lisbon, Portugal.
Pietro TiraboschiFondazione IRCCS Istituto Neurologico Carlo Besta, Via Giovanni Celoria, Milano, Italy.
Isabel SantanaUniversity Hospital of Coimbra (HUC), Neurology Service, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Alexander GerhardDivision of Psychology Communication and Human Neuroscience, Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.
Johannes LevinDepartment of Neurology, Ludwig-Maximilians Universität München, Munich, Germany.
Sandro SorbiDepartment of Neurofarba, University of Florence, Firenze, Italy.
Markus OttoDepartment of Neurology, University of Ulm, Ulm, Germany.
Florence PasquierUniversity Lille, Lille, France.
Simon DucharmeDouglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Canada.
Chris R ButlerNuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Headley Way, Headington, Oxford, UK.
Isabelle Le BerSorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Inserm U1127, CNRS UMR 7225, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France.
Elizabeth FingerDepartment of Clinical Neurological Sciences, University of Western Ontario, London, Canada.
James B RoweDepartment of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, Department of Clinical Neurosciences, Cambridge Biomedical Campus, Cambridge, UK.
Matthis SynofzikDepartment of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research & Centre of Neurology, University of Tübingen, Tübingen, Germany.
Fermin MorenoCognitive Disorders Unit, Department of Neurology, Hospital Universitario Donostia, San Sebastian, Gipuzkoa, Spain.
Barbara BorroniNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Piazza del Mercato, Brescia, Italy.
Brad F BoeveDepartment of Neurology, Mayo Clinic, Rochester, USA.
Adam L BoxerMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, Sandler Neurosciences Center, San Francisco, San Francisco, USA.
Howie J RosenMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, Sandler Neurosciences Center, San Francisco, San Francisco, USA.
Yolande A L PijnenburgAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, Amsterdam, the Netherlands.
Jonathan D RohrerDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
Maria Carmela TartagliaKrembil Research Institute, University Health Network, Toronto, Canada.
ALLFTD Consortium and the GENFI Consortium
Funding
Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI ADAM L. BOXER, Bradley F Boeve · 2019 to 2026
$120.9MNational Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MTDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MUniversity of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Thomas J. Grabowski · 2020 to 2026
$29.0MLongitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)U01AG045390 · NIA · MAYO CLINIC ROCHESTER · PI BOEVE, BRADLEY F, ROSEN, HOWARD J · 2014 to 2018
$16.9MTraining - The Frontotemporal Lobar Degeneration Clinical Research ConsortiumU54NS092089 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2014 to 2018
$6.4MGenetic basis of neuropsychiatric symptoms in Alzheimer's diseaseU01AG079850 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gary Wayne Beecham, Edward D Huey · 2023 to 2026
$3.0MNeuroanatomical associations with the factor structure underlying neuropsychiatric symptoms in Alzheimer's diseaseR01AG062268 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HUEY, EDWARD D · 2018 to 2022
$2.5MUsing RDoC Negative and Positive Valence Paradigms to Investigate the Mechanisms of Neuropsychiatric Symptoms (NPS) in Alzheimer's Disease and Related DementiasR01MH120794 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HUEY, EDWARD D · 2019 to 2023
$2.1MGenetic and Neuropathologic Underpinnings of Sex Differences in Lewy Body DementiasR00AG073453 · NIA · UNIVERSITY OF COLORADO DENVER · PI ECE BAYRAM · 2024 to 2026
$725kGenetic and Neuropathologic Underpinnings of Sex Differences in Lewy Body DementiasK99AG073453 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAYRAM, ECE · 2022 to 2023
$251kAlzheimer FoundationAlzheimer's Research UK Clinical Research Training Fellowship ARUK-CRF2017B-2Association for Frontotemporal Dementias Research 2009Bluefield ProjectBrain FoundationCambridge University Centre for Frontotemporal DementiaCanadian Institute of Health Research #327387Care Research University College London Hospitals Biomedical Research CentreCarlos III Health Institute PI19/01637Dementia FoundationDeutsche Forschungsgemeinschaft German Research Foundation 390857198EU Joint Programme-Neurodegenerative Disease Research 2019-02248EU Joint Programme-Neurodegenerative Disease Research-PrefrontalsEuropean Reference Network for Rare Neurological DiseasesFundació Marató de TV3, Spain 20143810Germany's Federal Ministry of Education and ResearchItalian Ministry of Health 733051042Lewy Body Dementia AssociationMedical Research Council MC_UU_00030/14Medical Research Council MR/T033371/1Miriam Marks Brain Research UK Senior FellowshipMRC Clinician Scientist Fellowship MR/M008525/1National Centralized Repository for Alzheimer's Disease and Related Dementias 09-02-03-00National Centralized Repository for Alzheimer's Disease and Related Dementias U24 AG21886National Institute for HealthNational Institute for Health Research Cambridge Biomedical Research Centre NIHR203312: BRC-1215-20014National Institute of Neurological Diseases and Stroke AG063911Netherlands Organization for Scientific Research HCMI 056-13-018NIA NIH HHS K99 AG073453NIA NIH HHS K99AG073453NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG066509NIA NIH HHS R00 AG073453NIA NIH HHS R01 AG062268NIA NIH HHS U01 AG045390NIA NIH HHS U01 AG079850NIA NIH HHS U19 AG063911NIA NIH HHS U24 AG021886NIMH NIH HHS R01 MH120794NINDS NIH HHS U54 NS092089Ontario Brain InstituteRegion Stockholm ALF-projectSwedish FTD Inititative-Schörling FoundationVetenskapsrådet 2019-0224Wellcome Trust 103838Wellcome Trust 220258Weston Brain InstituteZonMw Memorabel 733 051 042ZonMw Onderzoeksprogramma Dementie 10510032120002
Abstract
introductionHigher male prevalence in sporadic behavioral variant frontotemporal dementia (bvFTD) has been reported. We hypothesized differences in phenotypes between genetic and sporadic bvFTD females resulting in underdiagnosis of sporadic bvFTD females.
methodsWe included genetic and sporadic bvFTD patients from two multicenter cohorts. We compared behavioral and cognitive symptoms, and gray matter volumes, between genetic and sporadic cases in each sex.
resultsFemales with sporadic bvFTD showed worse compulsive behavior (p = 0.026) and language impairments (p = 0.024) compared to females with genetic bvFTD (n = 152). Genetic bvFTD females had smaller gray matter volumes than sporadic bvFTD females, particularly in the parietal lobe. DISCUSSION: Females with sporadic bvFTD exhibit a distinct clinical phenotype compared to females with genetic bvFTD. This difference may explain the discrepancy in prevalence between genetic and sporadic cases, as some females without genetic mutations may be misdiagnosed due to atypical bvFTD symptom presentation. HIGHLIGHTS: Sex ratio is equal in genetic behavioral variant of frontotemporal dementia (bvFTD), whereas more males are present in sporadic bvFTD. Distinct neuropsychiatric phenotypes exist between sporadic and genetic bvFTD in females. Phenotype might explain the sex ratio difference between sporadic and genetic cases.
Indexed as
Frontotemporal DementiaSex CharacteristicsAgedBrainCohort StudiesFemaleGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsPhenotypeSex Factorsbehavioral variant frontotemporal dementiaclinical diagnosisdiversitysex difference
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