ReviewCurrent pharmaceutical design2025
Phytoestrogens: A Promising Therapeutic Approach for Endometriosis Management, Insights from Preclinical and Clinical Studies.
Review in Current pharmaceutical design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
introductionEndometriosis is a prevalent gynecological disorder characterized by the growth of endometrial tissue outside the uterine cavity. The disease often involves internal organs and leads to chronic pelvic pain and infertility. While its pathogenesis remains incompletely understood, the disease is considered estrogen-dependent, and reducing estrogen levels is a primary clinical treatment strategy. Despite extensive research and diverse treatment modalities, including surgery and pharmacotherapy, current treatments are associated with significant complications and recurrence. This review aims to explore recent studies on phytoestrogens' therapeutic potential in endometriosis treatment by examining the underlying mechanisms contributing to their efficacy.
methodsAn extensive evaluation of Google Scholar and PubMed, utilizing relevant keywords including "Endometriosis, Phytoestrogen, Estrogen, inflammation, pelvic pain, and Infertility" was carried out to assess the potential therapeutic efficacy of phytoestrogens in managing endometriosis, based on recent research findings. This review considered a wide range of studies, including in vitro, in vivo, and clinical studies, as well as reviews and research articles, to provide a comprehensive overview of the current state of knowledge on this topic.
resultsPhytoestrogens, with their structural similarity to estrogen, have emerged as a novel therapeutic approach. These compounds compete for estrogen receptor binding, displaying anti-estrogenic or weak proestrogenic properties upon binding.
conclusionExhibiting anti-proliferative, antioxidant, anti-angiogenic, and pro-apoptotic properties, phytoestrogens have demonstrated substantial therapeutic potential in endometriosis management. Extensive cellular, animal, and clinical investigations support their therapeutic efficacy.
Indexed as
Identifiers
40277065What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.