ArticleAnnals of medicine2025
Accelerated senescence of bone marrow erythrocyte precursors in myelodysplastic syndrome.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMyelodysplastic syndromes (MDS) represent a heterogeneous group of clonal hematopoietic disorders characterized by ineffective haematopoiesis, refractory cytopenia, and an increased risk of progression to acute myeloid leukaemia. This study investigates the presence of cellular senescence in bone marrow (BM) CD235a
methodsWe assessed senescence-related markers and cell cycle distribution in BM CD235a
resultsMDS patients exhibited heightened cellular senescence characterized by increased SA-β-gal positivity, elevated p16
conclusionMDS patients have accelerated senescence of bone marrow erythrocyte precursors, which is related to their anaemia. The observed correlation underscores the potential significance of senescence-targeted interventions in managing anaemia in MDS.
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