ArticleNucleic acids research2025
antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation.
Article in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 403 papers.
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403 citing papers in PubMed.
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- Comparative Phylogenomics Reveals Conserved Protoilludene Synthase Neighbourhoods and Unevenly Distributed Biosynthetic Gene Cluster Families in Armillaria.Journal of fungi (Basel, Switzerland) · 2026Article
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- Draft genome sequences of 12 fungi occurring in cyanobacteria-dominated biotic soil crusts in the Sonoran Desert.Microbiology resource announcements · 2026Article
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343 more citing papers are in PubMed but not listed here.
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27 authors.
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Abstract
Microorganisms synthesize small bioactive compounds through their secondary or specialized metabolism. Those compounds play an important role in microbial interactions and soil health, but are also crucial for the development of pharmaceuticals or agrochemicals. Over the past decades, advancements in genome sequencing have enabled the identification of large numbers of biosynthetic gene clusters directly from microbial genomes. Since its inception in 2011, antiSMASH (https://antismash.secondarymetabolites.org/), has become the leading tool for detecting and characterizing these gene clusters in bacteria and fungi. This paper introduces version 8 of antiSMASH, which has increased the number of detectable cluster types from 81 to 101, and has improved analysis support for terpenoids and tailoring enzymes, as well as improvements in the analysis of modular enzymes like polyketide synthases and nonribosomal peptide synthetases. These modifications keep antiSMASH up-to-date with developments in the field and extend its overall predictive capabilities for natural product genome mining.
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