Evidence map›Paper›PMID 40276971›Full record

ArticleNucleic acids research2025

Prediction and quality assessment of protein quaternary structure models using the MultiFOLD2 and ModFOLDdock2 servers.

Liam J McGuffin, Shaima N Alhaddad, Behnosh Behzadi, Nicholas S Edmunds, Ahmet G Genc, Recep Adiyaman

Abstract read
In one paragraph

Article in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Stoic: fast and accurate protein stoichiometry prediction.Bioinformatics (Oxford, England) · 2026
    Article
  4. YdbL directly modulates YdbH-YnbE bridge formation to maintainbioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
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  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Liam J McGuffinSchool of Biological Sciences, University of Reading, Whiteknights, Reading RG6 6DH, United Kingdom.ORCID 0000-0003-4501-4767
Shaima N AlhaddadSchool of Biological Sciences, University of Reading, Whiteknights, Reading RG6 6DH, United Kingdom.
Behnosh BehzadiSchool of Biological Sciences, University of Reading, Whiteknights, Reading RG6 6DH, United Kingdom.
Nicholas S EdmundsSchool of Biological Sciences, University of Reading, Whiteknights, Reading RG6 6DH, United Kingdom.
Ahmet G GencSchool of Biological Sciences, University of Reading, Whiteknights, Reading RG6 6DH, United Kingdom.
Recep AdiyamanSchool of Biological Sciences, University of Reading, Whiteknights, Reading RG6 6DH, United Kingdom.

Funding

Biotechnology and Biological Sciences Research CouncilBiotechnology and Biological Sciences Research Council BB/T018496/1Kuwait Civil Service CommissionRepublic of Turkey Ministry of National Education
6 · The paper itself

Abstract

Understanding the structures of protein complexes is pivotal for breakthroughs in health, agriculture, bioengineering, and beyond. MultiFOLD2 and ModFOLDdock2 are leading servers for protein quaternary structure prediction and model quality assessment, respectively. MultiFOLD2 includes integrated stoichiometry prediction for quaternary structures and improved sampling and scoring, leading to high performance in continuous independent benchmarks such as CAMEO. ModFOLDdock2 uses a hybrid consensus approach to generate global and local quality scores for predicted quaternary structures. ModFOLDdock2 is integrated with MultiFOLD2 while also being available as a stand-alone server, enabling the independent evaluation of quaternary structure models from any source. Both servers have been independently rigorously evaluated, demonstrating high performance and ranking among the top servers in their respective categories in the recent CASP16 experiment. The MultiFOLD2 and ModFOLDdock2 servers are freely accessible through user-friendly web interfaces at https://www.reading.ac.uk/bioinf/.

Indexed as

Computational BiologyModels, MolecularProteinsProtein Structure, QuaternarySoftwareInternetProteins

Identifiers

PMID40276971
PMCPMC12230669

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.