ArticleNucleic acids research2025
FoldScript: a web server for the efficient analysis of AI-generated 3D protein models.
Article in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
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- Microtubule Engagement by the WD40-Containing Tail of Kinesin-4 KIF21B.bioRxiv : the preprint server for biology · 2026Article
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- Structural and enzymatic insights into QatD, a dual-function TatD-like nuclease in the QatABCD anti-phage defense system.Nucleic acids research · 2026Article
- Precision repurposing of clinically characterized molecules targeting dengue virus RNA-dependent RNA polymerase: an in silico identification and in vitro validation.Folia microbiologica · 2026Article
- The diabetic wound microenvironment drives emergence and maintenance of CovRS variants in group BInfection and immunity · 2026Article
- Unconventional vesicle transport driven by formin-actin-myosin working system during pollen germination.Science advances · 2026Article
- Genome evolution in parthenogenetic nematodes shaped by chromosome rearrangements and introgression.Genome research · 2026Article
- Mutation of a conserved lysine in the RdRp fingers domain broadly attenuates orthobunyaviruses.Communications biology · 2026Article
- Disruption of the structural maintenance of chromosomes 5/6 complex enables tumor mutagenesis.NAR cancer · 2026Article
- Structural analysis of the flexibility of the Ubl2 domain within the papain-like protease of SARS-CoV-2.Acta crystallographica. Section F, Structural biology communications · 2026Article
- Inactivation of Cysteine Synthase CysK-A enhances flocculation, biofilm formation, and sensitivity to oxidative stress inBiofilm · 2026Article
- CrLHP1-CrJAZ1 Module Regulates Monoterpenoid Indole Alkaloid Biosynthesis via JA Signaling inGenes · 2026Article
- GmTGA9-GmDYT1 Regulates Anther Wall Development to Affect Male Fertility in Soybean.Plants (Basel, Switzerland) · 2026Article
- Structural bases of signal generation and transduction by the SPS amino acid sensor of Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2026Article
- In silico structural and dynamic stability analysis of an endo-1,4-β-xylanase from Agrobacterium sp. strain DKPNP3, isolated from the gut of Gonocephalum sp.Antonie van Leeuwenhoek · 2026Article
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3 authors.
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Abstract
Artificial intelligence (AI)-based 3D protein modelling software have revolutionized structural biology, often predicting protein structures with unprecedented confidence. However, to get the most out of AI, it is advisable to consider the information provided by a set of 'best' models with similar reliability scores, rather than just the top-ranked model, and to compare the results of different AI predictors. Furthermore, the 'highest scoring' solution is not always the 'best' one, especially in the case of oligomeric models where it may be crucial to introduce experimental knowledge into their selection. Here, we present the FoldScript web server, which has been developed to address these issues. It can be used to gather and synthesize primary to quaternary structure information from a set of up to 25 AI-generated models. The analysis is presented in the form of a comprehensible flat figure and mosaics of 3D structures, allowing efficient visual inspection of structural differences. Another module identifies models with known intermolecular contacts. FoldScript is therefore a decision support tool designed to help a large community, whether or not they are structural biologists, to rationally select the most accurate model in an AI-driven modelling process. It is freely available without login requirement at https://foldscript.ibcp.fr.
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