Evidence map›Paper›PMID 40276953›Full record

ArticleJournal of the European Academy of Dermatology and Venereology : JEADV2025

Consensus on core domains for hand eczema trials: Signs, symptoms, control and quality of life.

Henriette Rönsch, Karl Philipp Drewitz, Amber Reck Atwater, Detlef Becker, Philipp Bentz, Richard Brans, Tricia Chong, Heinrich Dickel, Peter Elsner, Ana M Giménez-Arnau and 29 more

Abstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the European Academy of Dermatology and Venereology : JEADV, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Consensus on core domains for hand eczema trials: Signs, symptoms, control and quality of life.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Henriette RönschDepartment of Dermatology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.ORCID https://orcid.org/0000-0001-8649-9196
Karl Philipp DrewitzInstitute of Social Medicine and Health Systems Research, Medical Faculty, Otto von Guericke University, Magdeburg, Germany.ORCID https://orcid.org/0000-0003-0808-1987
Amber Reck AtwaterDepartment of Dermatology, George Washington University, Washington, DC, USA.
Detlef BeckerDepartment of Dermatology, University of Mainz, Mainz, Germany.
Philipp BentzDivision of Occupational Dermatology, Department of Dermatology, Ruprecht-Karls-University, Heidelberg, Germany.ORCID https://orcid.org/0000-0002-6474-192X
Richard BransDepartment of Dermatology, Environmental Medicine and Health Theory, Osnabrück University, Osnabrück, Germany.
Tricia ChongNational Skin Centre, Singapore, Singapore.
Heinrich DickelDepartment of Dermatology, Venereology and Allergology, St. Josef Hospital, University Medical Center, Ruhr University Bochum, Bochum, Germany.ORCID https://orcid.org/0000-0001-6837-4402
Peter ElsnerSRH Hospital Gera, Gera, Germany.ORCID https://orcid.org/0000-0001-7696-3274
Ana M Giménez-ArnauDepartment of Dermatology, Hospital del Mar Research Institute, Universitat Pompeu Fabra, Barcelona, Spain.ORCID https://orcid.org/0000-0001-5434-7753
Fabrizio GuarneriDermatology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.ORCID https://orcid.org/0000-0003-0805-8496
María Graciela Guzmán PereraDermatology Department, Hospital Angeles del Pedregal, Mexico City, Mexico.
Sarah IbrahimDepartment of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Dimitra KoumakiDermatology Department, University Hospital of Heraklion, Heraklion, Crete, Greece.ORCID https://orcid.org/0000-0001-7074-2374
Jamie KoelbelDepartment of Dermatology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Francesca Larese FilonClinical Unit of Occupational Medicine, University of Trieste, Trieste, Italy.ORCID https://orcid.org/0000-0002-7717-0417
Suzana Ljubojević HadžavdićDepartment of Dermatology and Venereology, University Hospital Center Zagreb, School of Medicine University of Zagreb, Zagreb, Croatia.ORCID https://orcid.org/0000-0002-3640-9567
Laura LomanDepartment of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0003-2731-9284
Mihaly MaturaDepartments of Dermatology, Norrlands University Hospital, Umeå, Sweden.ORCID https://orcid.org/0009-0004-9621-8537
Sonja MolinDivision of Dermatology, Queen's University, Kingston, Ontario, Canada.ORCID https://orcid.org/0000-0002-9383-034X
Robert OfenlochDivision of Occupational Dermatology, Department of Dermatology, Ruprecht-Karls-University, Heidelberg, Germany.ORCID https://orcid.org/0000-0002-3532-6110
Katharina PiontekInstitute of Social Medicine and Health Systems Research, Medical Faculty, Otto von Guericke University, Magdeburg, Germany.ORCID https://orcid.org/0000-0002-2667-6741
Radoslaw SpiewakDepartment of Experimental Dermatology and Cosmetology, Jagiellonian University Medical College, Krakow, Poland.ORCID https://orcid.org/0000-0001-5968-0555
Anne StrunkDepartment of Dermatology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Margo ReederDepartment of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0002-5008-8843
David ReissigDepartment of Dermatology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Thomas RustemeyerDepartment of Dermatology, Allergology and Occupational Dermatology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Marie-Louise SchuttelaarDepartment of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Dagmar SimonDepartment of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Manon SlootDepartment of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Markus F C SteinerNHS Grampian, Occupational Health Service, Aberdeen, UK.
Saïda TongalazaInstitute of Social Medicine and Health Systems Research, Medical Faculty, Otto von Guericke University, Magdeburg, Germany.
Skaidra ValiukevičienėDepartment of Skin and Venereal Diseases, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Maurice WaitekDivision of Occupational Dermatology, Department of Dermatology, Ruprecht-Karls-University, Heidelberg, Germany.
Elke WeisshaarDivision of Occupational Dermatology, Department of Dermatology, Ruprecht-Karls-University, Heidelberg, Germany.
Stefan WöhrlFloridsdorf Allergy Center (FAZ), Vienna, Austria.ORCID https://orcid.org/0000-0002-6324-0007
Doreen WolffInstitute of Social Medicine and Health Systems Research, Medical Faculty, Otto von Guericke University, Magdeburg, Germany.
Andrea BauerDepartment of Dermatology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Christian ApfelbacherInstitute of Social Medicine and Health Systems Research, Medical Faculty, Otto von Guericke University, Magdeburg, Germany.ORCID https://orcid.org/0000-0003-3805-8219

Funding

European Academy of Dermatology and Venereology PPRC-2023-0024
6 · The paper itself

Abstract

backgroundHand eczema (HE) is a common and complex skin disease. A uniform set of core outcomes and related measures for use in clinical trials is lacking, making it difficult to compare results across HE studies.

objectiveTo reach consensus on a set of core domains and subdomains that should be measured in future therapeutic HE trials.

methodsIn 2024, we conducted a two-round online Delphi (eDelphi) survey among international HE experts, including physicians, patients and their relatives, researchers and industry representatives. A domain/subdomain was included in the core set when ≥80% of participants rated is as 'critically important'; 50% agreement or less resulted in its exclusion. Results from 50% to 80% were deemed controversial and subject for further discussion. During a hybrid consensus meeting, the stakeholders reviewed, completed and, if necessary, revised the preliminary eDelphi consensus.

resultsIn the first and second round of the eDelphi, 208 and 134 persons, respectively, participated. Forty participants from 18 countries attended the consensus meeting. Consensus was reached to include the core domains 'signs of HE' (with five core subdomains), 'symptoms of HE' (two subdomains), 'HE-related quality of life' (four subdomains) and 'HE control over time' (four subdomains). The subdomains 'desquamation/scaling' and 'emotional impact/mental health' remained controversial. Consensus was reached that the domains 'skin barrier function' and 'patient-reported treatment experience' and 28 subdomains should not be part of the core outcome set.

conclusionsTo produce comparable and meaningful results, future trials evaluating the effectiveness of HE treatments should measure signs and symptoms of HE, HE-related quality of life and HE control over time as core outcome domains. The next step of the HE core outcome set initiative (HECOS) is to identify appropriate measurement instruments.

Indexed as

Clinical Trials as TopicEczemaHand DermatosesQuality of LifeDelphi TechniqueFemaleHumansMale

Identifiers

PMID40276953
PMCPMC12376261

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.