ArticleMovement disorders clinical practice2025
Investigating Dopamine Replacement-Associated Fluctuations in Cognition and Mood in Cognitively Unimpaired Parkinson's Disease.
Article in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Apathy in Parkinson's Disease: Distinguishing Overlapping Symptoms Via Network Analysis.Movement disorders clinical practice · 2026Article
- Cognitive Fluctuations, Neuropsychiatric Burden, and Quality of Life in Moderate-Advanced Dementia With Lewy Bodies: The Role of Dysautonomia.Neurology · 2026Observational
- Early Autonomic Burden in Prodromal Parkinson's Disease Predicts Cognitive Impairment.Movement disorders : official journal of the Movement Disorder Society · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundNon-motor fluctuations, characterized by variability in mood and cognition, are prevalent in advanced Parkinson's disease (PD), but less is known about these fluctuations in early PD.
objectiveThe objective was to characterize fluctuations in cognition and mood in early PD without cognitive impairment.
methodsIndividuals with PD but without cognitive impairment were evaluated "on" and "off" dopaminergic medications for minimal clinically important differences (MCID) in depression, anxiety, and cognition. Multivariable logistic regression evaluated factors associated with medication-related fluctuations in anxiety, depression, and cognition.
resultsClinically meaningful fluctuations in anxiety were associated with dysautonomia (OR [odds ratio] 7.5) and female sex (OR 3.9). Fluctuations in Symbol Digit Modalities Test (SDMT), a measure of processing speed and executive function, were associated with dysautonomia (OR 2.82). Such an association was not found with depression or Stroop test.
conclusionsDysautonomia may influence fluctuations in anxiety and some aspects of cognition in cognitively unimpaired PD.
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Registered trials
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