Evidence map›Paper›PMID 40276862›Full record

SynthesisThe Journal of international medical research2025

Effectiveness and safety of topical phosphodiesterase 4 inhibitors in children with mild-to-moderate atopic dermatitis: A systematic review and meta-analysis.

Long Wang, Lequ Zeng, Yuyu Wu, Min Zhong, Lizhen Zhang, Chen Li

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Long WangDepartment of Dermatology and Venereology, Zhongshan City People's Hospital, Zhong Shan, China.
Lequ ZengDepartment of Dermatology and Venereology, Zhongshan City People's Hospital, Zhong Shan, China.
Yuyu WuDepartment of Dermatology and Venereology, Zhongshan City People's Hospital, Zhong Shan, China.
Min ZhongDepartment of Dermatology and Venereology, Zhongshan City People's Hospital, Zhong Shan, China.
Lizhen ZhangDepartment of Dermatology and Venereology, Zhongshan City People's Hospital, Zhong Shan, China.
Chen LiDepartment of Dermatology and Venereology, Zhongshan City People's Hospital, Zhong Shan, China.ORCID 0009-0001-0874-8203

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectiveTo evaluate the efficacy and adverse effects of phosphodiesterase 4 inhibitors in children with mild-to-moderate atopic dermatitis.MethodsElectronic searches were conducted based on PubMed, Cochrane Library, EMBASE, and Web of Science using Medical Subject Headings terms and relevant keywords. Using response rates as the primary outcome and adverse effects as the secondary outcome, statistical analysis was performed via Stata 15.1 SE, with Cochrane Q and

Indexed as

Dermatitis, AtopicPhosphodiesterase 4 InhibitorsAdministration, TopicalChildHumansRandomized Controlled Trials as TopicSeverity of Illness IndexTreatment OutcomePhosphodiesterase 4 Inhibitorsadverse effectsAtopic dermatitiscrisaboroleE6005meta-analysisOPA-15406phosphodiesterase 4 inhibitors

Identifiers

PMID40276862
PMCPMC12035403

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.