ReviewThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi2025
Application of Steatotic Donor Livers in Liver Transplantation.
Review in The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Galectin-3 Promotes Graft Injury via NLRP3 Pyroptosis in Steatotic Liver Transplantation: A Therapeutic Target for Donor Optimization.Journal of clinical and translational hepatology · 2026Article
- Targeting ferroptosis and mitochondrial ROS: organoprotective mechanisms of anesthetic conditioning in liver transplantation.Frontiers in molecular biosciences · 2026Review
- Pathogenesis of metabolic dysfunction-associated steatotic liver disease and donor liver damage.iLIVER · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The growing prevalence of fatty liver disease in donor livers has become a critical focus in liver transplantation due to the global shortage of viable grafts. This article reviews the challenges and advancements in utilizing steatotic donor livers, emphasizing their increased risk of post-transplant complications, such as primary non-function and early allograft dysfunction. Mechanistically, macrovesicular and microvesicular steatosis differentially impair lipid metabolism, exacerbate ischemia-reperfusion injury (IRI), and disrupt hepatic microcirculation, contributing to graft failure. Innovations in donor assessment, including magnetic resonance imaging-proton density fat fraction and AI-enhanced imaging, have improved fat quantification accuracy, while machine perfusion techniques (e.g., hypothermic oxygenated perfusion and normothermic machine perfusion) show promise in mitigating IRI and enhancing preservation, particularly for marginal steatotic livers. However, controversies persist regarding standardized fat-content thresholds, ischemia tolerance limits, and heterogeneity in risk stratification. Future research highlights the need for non-invasive subtyping technologies, dynamic preservation strategies guided by real-time biomarkers, and multi-omics approaches to unravel steatosis-related molecular pathways. Addressing these challenges may expand the safe use of steatotic grafts and alleviate organ shortages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.