Evidence map›Paper›PMID 40276805›Full record

ArticleMolecular pharmaceutics2025

Interactions of Sucrose and Trehalose with Lysozyme in Different Media: A Perspective from Atomistic Molecular Dynamics Simulations.

Inna Ermilova, Jan Swenson

Abstract read
In one paragraph

Article in Molecular pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Inna ErmilovaDepartment of Physics, Chalmers University of Technology, 412 96 Gothenburg, Sweden.ORCID 0000-0001-7371-8644
Jan SwensonDepartment of Physics, Chalmers University of Technology, 412 96 Gothenburg, Sweden.ORCID 0000-0001-5640-4766

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disaccharides are promising additives for stabilizing proteins in, e.g., pharmaceuticals and cryopreserved biomaterials. However, although many studies have shown that disaccharides exhibit such bioprotective and stabilizing properties, the underlying molecular mechanism is still elusive. In this study, we have tried to reach such an understanding by studying lysozyme in aqueous solutions of sucrose or trehalose and various ions (0.1 M Cl

Indexed as

MuramidaseSucroseTrehaloseChloridesHydrogen BondingMolecular Dynamics SimulationSodium ChlorideWaterZinc CompoundsChloridesMuramidaseSodium ChlorideSucroseTrehaloseWaterzinc chlorideZinc CompoundsCHARMM36 force fieldgeneral Amber force fieldlysozymemolecular dynamicssucrosetrehalose

Identifiers

PMID40276805
PMCPMC12135068

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.