Evidence map›Paper›PMID 40276764›Full record

ArticleiScience2025

Type I interferon signaling controls the early hematopoietic expansion in response to β-glucan.

Yangsong Xu, Man K S Lee, Nicole A de Weerd, Ziyue Fu, Camilla Bertuzzo Veiga, Dragana Dragoljevic, Dmitri Sviridov, Paul J Hertzog, Andrew J Fleetwood, Andrew J Murphy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yangsong XuHaematopoiesis and Leukocyte Biology, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.
Man K S LeeHaematopoiesis and Leukocyte Biology, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.
Nicole A de WeerdCentre for Innate Immunity and Infectious Diseases, Department of Molecular and Translational Science, Hudson Institute of Medical Research and Monash University, Clayton, VIC, Australia.
Ziyue FuHaematopoiesis and Leukocyte Biology, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.
Camilla Bertuzzo VeigaHaematopoiesis and Leukocyte Biology, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.
Dragana DragoljevicHaematopoiesis and Leukocyte Biology, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.
Dmitri SviridovLipoproteins and Atherosclerosis, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.
Paul J HertzogCentre for Innate Immunity and Infectious Diseases, Department of Molecular and Translational Science, Hudson Institute of Medical Research and Monash University, Clayton, VIC, Australia.
Andrew J FleetwoodHaematopoiesis and Leukocyte Biology, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.
Andrew J MurphyHaematopoiesis and Leukocyte Biology, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapid hematopoietic adaptations are important for building and sustaining the biological response to β-glucan. The signals involved in these early events have not yet been fully explored. Given that type I interferons are produced in response to β-glucan and can profoundly impact hematopoietic stem cell (HSC) function, we hypothesized that this pathway may be involved in the early bone marrow response to β-glucan.

Indexed as

Cell biologyFunctional aspects of cell biologyImmune responseImmunology

Identifiers

PMID40276764
PMCPMC12020881

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.