Evidence map›Paper›PMID 40276739›Full record

ArticleFrontiers in medicine2025

Impact of preoperative intraocular pressure on corneal endothelial cell loss after phacoemulsification in acute primary angle-closure glaucoma with cataracts.

Jiaqi Shen, Xin Liu, Mingyue Lin, Yuting Shao, Guozhen Niu, Shen Qu, Yunli Niu, Qi Zhou, Li Zhang, Yanlong Bi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiaqi Shen *Department of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Xin Liu *Department of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Mingyue LinDepartment of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Yuting ShaoDepartment of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Guozhen NiuDepartment of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Shen QuDepartment of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Yunli NiuDepartment of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Qi ZhouTongji Eye Institute, School of Medicine, Tongji University, Shanghai, China.
Li Zhang *Department of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Yanlong Bi *Department of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aimed to assess corneal endothelial cell loss (ECL) following phacoemulsification and intraocular lens implantation (Phaco+IOL) in eyes with acute primary angle-closure glaucoma (APACG) and cataracts under different preoperative intraocular pressure (IOP) levels. Methods: This non-randomized controlled trial included 75 eyes from 75 patients with APACG and cataracts who underwent Phaco+IOL. All patients received pharmacotherapy and anterior chamber paracentesis before surgery and were grouped according to their preoperative IOP: the high-IOP group (IOP ≥ 25 mmHg) and the IOP-controlled group (IOP < 25 mmHg). IOP, visual outcome, endothelial cell density (ECD), hexagonality (HEX), coefficient of variation (CV), and central corneal thickness (CCT) were evaluated up to 3 months postoperatively. Baseline ECD, HEX, and CV parameters were measured in the contralateral eyes of all patients as a reference and compared with the postoperative results. Results: The average IOP decreased from 43.2 ± 4.8 mmHg to 16.5 ± 5.8 mmHg ( Conclusion: Uncontrolled high IOP (≥ 25 mmHg) before Phaco+IOL in patients with APACG and cataracts is associated with a higher rate of ECL. The rapid and substantial reduction of IOP during surgery may exacerbate corneal endothelial cell loss. Clinical trial registration: ClinicalTrails.gov, identifier ChiCTR2100052096.

Indexed as

acute primary angle-closure glaucomacorneal endothelial cell lossendothelial cell densityocular hypertensionphacoemulsification

Identifiers

PMID40276739
PMCPMC12018442

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.