Evidence map›Paper›PMID 40276724›Full record

SynthesisFrontiers in aging2025

Global research trends in inflammaging from 2005 to 2024: a bibliometric analysis.

Beier Jiang, Yi-Ni Dong, Yu Xiong, Chun-Xia Jiang, Jun Ping, Qi Wu, Liu-Jun Xu, Run-Zhe Shu, Dan-Dan Gao, Sheng-Mei Zhu and 2 more

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Insulin Resistance and Inflammation.International journal of molecular sciences · 2026
    Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Beier Jiang *Department of Respiratory and Critical Care, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, China.
Yi-Ni Dong *Wenzhou Medical University, Wenzhou, China.
Yu XiongWenzhou Medical University, Wenzhou, China.
Chun-Xia JiangThe Joint Innovation Center for Engineering in Medicine, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, China.
Jun PingThe Joint Innovation Center for Engineering in Medicine, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, China.
Qi WuThe Joint Innovation Center for Engineering in Medicine, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, China.
Liu-Jun XuDepartment of Respiratory and Critical Care, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, China.
Run-Zhe ShuDepartment of Respiratory and Critical Care, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, China.
Dan-Dan GaoWenzhou Medical University, Wenzhou, China.
Sheng-Mei ZhuThe Joint Innovation Center for Engineering in Medicine, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, China.
Wei-Dong YeThe Joint Innovation Center for Engineering in Medicine, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, China.
Feng ZhangDepartment of Respiratory and Critical Care, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Inflammaging, defined as chronic low-grade inflammation associated with aging, is considered a key factor in many age-related diseases. Despite growing research, comprehensive assessments of trends and focuses on this field over the past 2 decades remain lacking. Objective: To comprehensively analyze literature development trends, scientific priorities, and their evolution in the field of inflammaging from 2005 to 2024 using bibliometric analysis. Methods: Academic literature on inflammaging was retrieved from the Web of Science Core Collection. CiteSpace software was used as the bibliometric tool to analyze annual publication trends, contributing countries/regions, leading research institutions, primary journals, and keyword co-occurrence, including clustering and burst analysis in this field. Results: The study included 1,800 eligible articles, demonstrating a consistent growth in research publications over the past 20 years. The United States and Italy were the principal contributors. The University of Bologna had the highest publication. Professor Claudio Franceschi has been a leading figure in this field. Journal analysis shows that research themes predominantly focus on molecular biology/immunology and medicine/clinical fields. Keyword analysis identifies major research hotspots as "inflammaging," "Crohn's disease," "periodontitis," "immunosenescence," "skeletal muscle," "gut microbiota," and "Parkinson's disease." Emerging term analysis indicates a shift from specific inflammatory diseases to broader aging and immune modulation studies. Conclusion: This first systematic assessment of literature trends in the field of inflammaging from 2005 to 2024 reveals sustained academic growth and an increasingly deep research focus.

Indexed as

bibliometricsimmunosenescenceinflammagingresearch hotspotsscientific trends

Identifiers

PMID40276724
PMCPMC12018403

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.