Regulation of perisomatic synapses from cholecystokinin basket interneurons through NrCAM and Ankyrin B.

Erik N Oldre, Barrett D Webb, Justin E Sperringer, Patricia F Maness

Abstract read

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Article in Current research in neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Impulsivity in NrCAM KO Mice Is Reduced by NMDAR Antagonist MK-801 but Not by AMPAR Antagonist CNQX.NeuroSci · 2026
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Update of
Regulation of Perisomatic Synapses from Cholecystokinin Basket Interneurons through NrCAM and Ankyrin B.2025

5 · Who and what money

Authors and funding

4 authors.

Erik N OldreDepartment of Biochemistry and Biophysics, CB 7260, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA.

Barrett D WebbDepartment of Biochemistry and Biophysics, CB 7260, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA.

Justin E SperringerDepartment of Biochemistry and Biophysics, CB 7260, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA.

Patricia F ManessDepartment of Biochemistry and Biophysics, CB 7260, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA.

Funding

Molecular Mechanisms of Developmental Spine RemodelingR56MH113280 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MANESS, PATRICIA F · 2022 to 2023

$778k

NIMH NIH HHS R56 MH113280

6 · The paper itself

Abstract

The perisomatic region of cortical pyramidal neurons (PNs) integrates local and long-range inputs and regulates firing. This domain receives GABAergic inputs from cholecystokinin (CCK)- and Parvalbumin (PV)-expressing basket cells (BCs) but how synaptic contacts are established is unclear. Neuron-glial related cell adhesion molecule (NrCAM) is a homophilic transmembrane protein that binds the scaffold protein Ankyrin B. Here we show that NrCAM and Ankyrin B mediate perisomatic synaptic contact between CCK-BCs and PNs in mouse medial prefrontal cortex (mPFC). Immunolabeling of CCK-BC terminals for vesicular glutamate transporter-3 (VGLUT3) or vesicular GABA transporter (VGAT) revealed a significant decrease in CCK-BC synaptic puncta on PN soma in NrCAM-null mice, however no decrease in PV-BC puncta or cell loss. VGLUT3+ CCK-BC puncta were also decreased by Ankyrin B deletion from PNs in Nex1Cre-ERT2:Ank2

Indexed as

AnkyrinCell adhesionCholecystokinin-basket interneuronsNrCAMSynapse

Identifiers

PMID40276719

DOI10.1016/j.crneur.2025.100150

PMCPMC12018208

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