ArticleRegenerative therapy2025
Operator stress factors and cell contamination risks in cell processing facilities: An online survey-based analysis.
Article in Regenerative therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Biosafety-cabinet wipe-cleaning assessment system: Integration of visual, thermal, and pressure sensing.Regenerative therapy · 2026Article
- Metagenomic-driven predictive biosafety and contamination traceability in stem cell manufacturing: Translating outbreak genomics into regenerative medicine.Regenerative therapy · 2026Review
- Optimized personnel flow with minimal contamination: development and validation of an air-barrier cleanroom for cell products processing.Regenerative therapy · 2025Article
- Microbiome-based profiles of airborne bacteria to support microbial risk assessment in cleanroom environments.Regenerative therapy · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The field of regenerative medicine is rapidly evolving, with an increasing number of approved cell preparations. However, cell processing facilities (CPFs) still heavily rely on manual operations by cell processing operators (CPOs). The intricate nature of cell culture and stringent sterility requirements impose a considerable psychological burden on CPOs, particularly the risk of cell contamination. This study delves into the psychological aspects experienced by CPOs in relation to the risk of contamination during cell culture. An online survey was conducted across 47 sites to investigate concerns regarding contamination and the strategies implemented to mitigate contamination risk in cell processing facilities. The survey findings revealed that 72 % of operators expressed concern about contamination, with 18 % reporting direct experiences of contamination. This indicates that the perceived contamination risk in CPFs is higher than the actual reported incidents. Furthermore, this study examines operational practices, such as material handling, and the utilization of biological safety cabinets (BSCs). The results highlight variations in BSC utilization and material handling practices, underscoring potential operational challenges. Implementing risk assessments and leveraging evidence-based data at each site could help address these challenges and alleviate the psychological strain on CPOs. This, in turn, would enhance the quality of cell therapy products and improve the well-being of CPOs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.