Evidence map›Paper›PMID 40276634›Full record

ArticleChemical science2025

Direct single-nucleotide resolution sequencing of DNA 5-methylcytosine using engineered DNA methyltransferase-mediated CMD-seq.

Wei Liu, Zhao-Cheng Ma, Shan Zhang, Fang-Yin Gang, Tong-Tong Ji, Yao-Hua Gu, Neng-Bin Xie, Shu-Yi Gu, Xia Guo, Tian Feng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wei LiuDepartment of Occupational and Environmental Health, School of Public Health, Wuhan University, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University Wuhan 430071 China liuyu97@whu.edu.cn jxiong@whu.edu.cn bfyuan@whu.edu.cn.
Zhao-Cheng MaDepartment of Occupational and Environmental Health, School of Public Health, Wuhan University, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University Wuhan 430071 China liuyu97@whu.edu.cn jxiong@whu.edu.cn bfyuan@whu.edu.cn.
Shan ZhangDepartment of Occupational and Environmental Health, School of Public Health, Wuhan University, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University Wuhan 430071 China liuyu97@whu.edu.cn jxiong@whu.edu.cn bfyuan@whu.edu.cn.
Fang-Yin GangDepartment of Occupational and Environmental Health, School of Public Health, Wuhan University, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University Wuhan 430071 China liuyu97@whu.edu.cn jxiong@whu.edu.cn bfyuan@whu.edu.cn.
Tong-Tong JiDepartment of Occupational and Environmental Health, School of Public Health, Wuhan University, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University Wuhan 430071 China liuyu97@whu.edu.cn jxiong@whu.edu.cn bfyuan@whu.edu.cn.
Yao-Hua GuDepartment of Occupational and Environmental Health, School of Public Health, Wuhan University, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University Wuhan 430071 China liuyu97@whu.edu.cn jxiong@whu.edu.cn bfyuan@whu.edu.cn.
Neng-Bin XieDepartment of Occupational and Environmental Health, School of Public Health, Wuhan University, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University Wuhan 430071 China liuyu97@whu.edu.cn jxiong@whu.edu.cn bfyuan@whu.edu.cn.
Shu-Yi GuDepartment of Occupational and Environmental Health, School of Public Health, Wuhan University, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University Wuhan 430071 China liuyu97@whu.edu.cn jxiong@whu.edu.cn bfyuan@whu.edu.cn.
Xia GuoDepartment of Occupational and Environmental Health, School of Public Health, Wuhan University, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University Wuhan 430071 China liuyu97@whu.edu.cn jxiong@whu.edu.cn bfyuan@whu.edu.cn.
Tian FengDepartment of Occupational and Environmental Health, School of Public Health, Wuhan University, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University Wuhan 430071 China liuyu97@whu.edu.cn jxiong@whu.edu.cn bfyuan@whu.edu.cn.
Yu LiuDepartment of Occupational and Environmental Health, School of Public Health, Wuhan University, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University Wuhan 430071 China liuyu97@whu.edu.cn jxiong@whu.edu.cn bfyuan@whu.edu.cn.
Jun XiongDepartment of Occupational and Environmental Health, School of Public Health, Wuhan University, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University Wuhan 430071 China liuyu97@whu.edu.cn jxiong@whu.edu.cn bfyuan@whu.edu.cn.
Bi-Feng YuanDepartment of Occupational and Environmental Health, School of Public Health, Wuhan University, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University Wuhan 430071 China liuyu97@whu.edu.cn jxiong@whu.edu.cn bfyuan@whu.edu.cn.ORCID https://orcid.org/0000-0001-5223-4659

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

5-Methylcytosine (5mC) is a crucial epigenetic modification in the mammalian genome, primarily occurring at CG dinucleotides. Accurate localization of 5mC is essential for understanding its functional significance. In this study, we discovered a novel DNA methyltransferase, designated M.MedI, from the bacterium

Identifiers

PMID40276634
PMCPMC12015181

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.