Article3 Biotech2025
High resilience of human cerebellum in Alzheimer's disease: reciprocal coupling of cellular anabolic and catabolic fluxes enable intensive neuroprotection.
Article in 3 Biotech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Effects of a short-term multicomponent functional exercise program on the serum proteome: an exploratory study in hospitalized older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Trial
- Glial Cells and Aging: From the CNS to the Cerebellum.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We elucidate that the cerebellum displays striking resilience to neurodegenerative changes under aging or Alzheimer's disease (AD). We identify the neurobiological factors that underlie the natural neuroprotective characteristic of cerebellum, thereby obtaining innovative therapeutic directions that may duplicate this naturalistic neurorestorative response. We investigated the mass spectrometry/liquid chromatography-based proteomics profile from AD tissue: sparely affected cerebellum and highly affected hippocampus/cingulate/entorhinal cortex. We found 83 upregulated and 37 downregulated cerebellar genes. Top five upregulated genes were Supplementary Information: The online version contains supplementary material available at 10.1007/s13205-025-04264-y.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.