ArticleJournal of exercise science and fitness2024
Dose-response relationship between leisure-time physical activity patterns and phenotypic age acceleration in American adults: A cross-sectional analysis.
Article in Journal of exercise science and fitness, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Body mass index, physical activity, and epigenetic aging: a cross-population study.Clinical epigenetics · 2026Observational
- Lifestyle factors and DNA methylation-based aging clocks: cross-sectional and longitudinal associations in the Singapore diet and healthy aging cohort.The journal of prevention of Alzheimer's disease · 2026Article
- Associations of physical activity domains and delayed biological aging: assessing heterogeneity and interaction of effects.Biology of sport · 2026Article
- Dose response of leisure time physical activity and biological aging in type 2 diabetes: a cross sectional study.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/Objectives: With the accelerating global population aging, delaying aging and promoting healthy aging have become focal points in public health and clinical medicine. Phenotypic age acceleration (PhenoAgeAccel) is an important indicator of biological aging speed. This study aims to explore the relationship between different leisure-time physical activity (LTPA) patterns and PhenoAgeAccel, analyzing the association and dose-response relationship. Methods: This study utilized data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018, including 14,868 adults. Multivariable linear regression models and restricted cubic spline methods were used to assess the relationship between LTPA and PhenoAgeAccel, with segmented likelihood ratio tests to detect non-linear thresholds. Stratified regression and interaction tests explored potential modifications by sex, age, race, and socioeconomic status. Results: Compared to individuals with no LTPA, those with inactive and regular LTPA patterns had significantly lower PhenoAgeAccel scores ( Conclusion: Regular LTPA significantly reduces phenotypic age acceleration, with a non-linear threshold effect indicating moderate physical activity is most beneficial. The weekend warrior pattern was less effective. These findings highlight the necessity of personalized physical activity recommendations and provide evidence for public health strategies to promote healthy aging.
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Registered trials
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