ArticleFrontiers in neuroscience2025
Functional connectivity of default mode network in non-hospitalized patients with post-COVID cognitive complaints.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Investigation of BOLD signal intensities in long COVID patients using 7T functional MRI.Brain, behavior, & immunity - health · 2026Article
- Brain dynamics of attentional, default-mode and limbic networks are disrupted at rest in post-COVID-19 syndrome.Brain, behavior, & immunity - health · 2026Article
- Introducing Structural Reliance: A New Method to Assess Structure-Function Coupling in the Brain.Human brain mapping · 2026Article
- Brain connectivity and its relation to cognitive function in patients with post-COVID 19 condition after mild infection.Scientific reports · 2026Article
- Photobiomodulation for cognitive dysfunction (Brain Fog) in post-COVID-19 condition: a randomized double-blind sham-controlled pilot trial.EClinicalMedicine · 2026Article
- Postsurgical perilesional functional connectivity predicts neurological outcome in glioma patients.Frontiers in neuroscience · 2026Article
- Immunomodulatory Mechanisms Underlying Neurological Manifestations in Long COVID: Implications for Immune-Mediated Neurodegeneration.International journal of molecular sciences · 2025Review
- Multimodal MRI reveals consistent basal ganglia and limbic system alterations in COVID-19 survivors.Imaging neuroscience (Cambridge, Mass.) · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Introduction: Neurologic impairment is common in patients with acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. While patients with severe COVID have a higher prevalence of neurologic symptoms, as many as one in five patients with mild COVID may also be affected, exhibiting impaired memory as well as other cognitive dysfunctions. Methods: To characterize the effect of COVID on the brain, the current study recruited a group of adults with post-COVID cognitive complaints but with mild, non-hospitalized cases. They were then evaluated through formal neuropsychological testing and underwent functional MRI of the brain. The participants in our study performed nearly as expected for cognitively intact individuals. Additionally, we characterized the functional connectivity of the default mode network (DMN), which is known for cognitive functions including memory as well as the attention functions involved in normal aging and degenerative diseases. Results: Along with the retention of functional connectivity in the DMN, our results found the DMN to be associated with neurocognitive performance through region-of-interest and whole-brain analyses. The connectivity between key nodes of the DMN was positively correlated with cognitive scores ( Discussion: Our findings provide neuroimaging evidence of the functional connectivity of brain networks among individuals experiencing cognitive deficits beyond the recovery of mild COVID. These imaging outcomes indicate expected functional trends in the brain, furthering understanding and guidance of the DMN and neurocognitive deficits in patients recovering from COVID.
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