Evidence map›Paper›PMID 40276564›Full record

ArticleBiological psychiatry global open science2025

Eating Disorders and Later Incidence of Cancer: A Nationwide Longitudinal Study in Denmark.

Gabrielle E Cooper, Natalie M Papini, Katrine Holde, Cynthia M Bulik, Zeynep Yilmaz, Liselotte V Petersen

Abstract read
In one paragraph

Article in Biological psychiatry global open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gabrielle E CooperDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Natalie M PapiniDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Katrine HoldeNational Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
Cynthia M BulikDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Zeynep YilmazDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Liselotte V PetersenNational Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.

Funding

Eating Disorders Genetics Initiative (EDGI)R01MH120170 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M · 2019 to 2023
$7.2M
Predicting the multi-omic impact of psychiatric GWAS associationsR01MH118278 · NIMH · YALE UNIVERSITY · PI HUCKINS, LAURA MARIANNE · 2019 to 2023
$3.6M
1/7 PGC: Advancing Discovery and ImpactR01MH124871 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, SULLIVAN, PATRICK F · 2021 to 2025
$3.5M
Predicting Binge and Purge Episodes from Passive and Active Apple Watch Data Using a Dynamical Systems ApproachR01MH119084 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, BUTNER, JONATHAN · 2019 to 2022
$2.8M
3/3 Eating Disorders Genetics Initiative 2 (EDGI2)R01MH136156 · NIMH · KAROLINSKA INSTITUTE · PI Lisa Dinkler, Lu Yi · 2024 to 2026
$1.5M
Genetic Architecture of Avoidant/Restrictive Food Intake DisorderR56MH129437 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, MICALI, NADIA · 2022 to 2023
$1.5M
NIMH NIH HHS R01 MH118278NIMH NIH HHS R01 MH119084NIMH NIH HHS R01 MH120170NIMH NIH HHS R01 MH124871NIMH NIH HHS R01 MH136156NIMH NIH HHS R56 MH129437
6 · The paper itself

Abstract

Background: We examined the incidence of cancer types among individuals with eating disorders (EDs). Methods: A nationwide longitudinal study of 6,807,731 individuals born between 1940 and 2015 was conducted using the Danish National Registries. Cox models with ED diagnosis as exposure and cancer diagnoses as outcomes were used to estimate hazard ratios (HRs) and 95% CIs while adjusting for sex, birth year, and comorbidities. The primary analysis comprised ICD-8 and ICD-10 codes for anorexia nervosa (AN) and other ED (OED). The secondary analysis comprised ICD-10 codes and included AN, bulimia nervosa (BN), and eating disorders not otherwise specified (EDNOS). Results: AN was associated with a reduced incidence of breast cancer while adjusting for sex and birth year (HR, 0.80; 95% CI, 0.66-0.97) and elevated incidence of respiratory (HR, 1.59; 95% CI, 1.24-2.04), cervical (HR, 1.45; 95% CI, 1.05-1.98), and esophageal (HR, 4.77; 95% CI, 2.82-8.06) cancers. OED was associated with an elevated incidence of respiratory (HR, 1.57; 95% CI, 1.20-2.06) and cervical (HR, 1.60; 95% CI, 1.20-2.14) cancers. ICD-10-only analyses confirmed the association of AN with reduced incidence of breast cancer and elevated incidence of respiratory and cervical cancers. BN was associated with reduced incidence of breast cancer in sensitivity analysis. EDNOS was associated with reduced incidence of breast cancer and elevated incidence of respiratory and cervical cancers. Conclusions: All EDs were associated with a reduced incidence of breast cancer. All EDs except BN were associated with a higher incidence of respiratory and cervical cancers. AN was associated with a higher incidence of esophageal cancer.

Indexed as

Anorexia nervosaBreastBulimia nervosaCancerIncidenceRespiratory

Identifiers

PMID40276564
PMCPMC12019012

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.