Evidence map›Paper›PMID 40276483›Full record

ArticleJHEP reports : innovation in hepatology2025

Recurrence of autoimmune hepatitis cholestatic variant syndromes after liver transplantation affects graft and patient survival.

Vincenzo Ronca, Alessandro Parente, Ellina Lytvyak, Bettina E Hansen, Gideon Hirschfield, Alan Bonder, Maryam Ebadi, Saleh Elwir, Mohamad Alsaed, Piotr Milkiewicz and 60 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JHEP reports : innovation in hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

70 authors.

Vincenzo RoncaDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Alessandro ParenteInstitute of Liver Studies, King's College Hospital NHS Foundation Trust, Denmark Hill, SE59RS, London, UK.
Ellina LytvyakDepartment of Medicine, University of Alberta, Edmonton, AB, Canada.
Bettina E HansenDepartment of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands.
Gideon HirschfieldToronto Center for Liver Disease, University Health Network, University of Toronto, Toronto, ON, Canada.
Alan BonderBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Maryam EbadiDivision of Gastroenterology and Liver Unit, University of Alberta, Edmonton, AB, Canada.
Saleh ElwirBaylor University Medical Center, Dallas, TX, USA.
Mohamad AlsaedBaylor University Medical Center, Dallas, TX, USA.
Piotr MilkiewiczEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Maciej K JanikEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Hanns-Ulrich MarschallEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Maria Antonella BurzaEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Cumali EfeDepartment of Gastroenterology, Harran University Hospital, Şanlıurfa, Turkey.
Ali Rıza CalışkanDepartment of Gastroenterology, Adiyaman University School of Medicine, Adiyaman, Turkey.
Murat HarputluogluDepartment of Gastroenterology, Inönü University School of Medicine, Malatya, Turkey.
Gökhan KabaçamClinic of Gastroenterology and Liver Transplantation, Guven Hospital, Ankara, Turkey.
Débora TerrabuioDepartment of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil.
Fernanda de Quadros OnofrioToronto Center for Liver Disease, University Health Network, University of Toronto, Toronto, ON, Canada.
Nazia SelznerToronto Center for Liver Disease, University Health Network, University of Toronto, Toronto, ON, Canada.
Albert ParésEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Laura LlovetEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Murat AkyıldızKoç University School of Medicine, Department of Gastroenterology and Liver Transplantation Center, Istanbul, Turkey.
Cigdem ArikanKoc University School of Medicine Pediatric Gastroenterology and Hepatology, Organ Transplantation Center, Koc University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey.
Mihael P MannsEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Richard TaubertEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Anna-Lena WeberEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Thomas D SchianoRecanati/Miller Transplantation Institute/Division of Liver Diseases, Mount Sinai Medical Center, New York, NY, USA.
Brandy HaydelRecanati/Miller Transplantation Institute/Division of Liver Diseases, Mount Sinai Medical Center, New York, NY, USA.
Piotr CzubkowskiEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Piotr SochaEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Natalia OłdakEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Nobuhisa AkamatsuHepato-Biliary-Pancreatic Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
Atsushi TanakaDepartment of Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Cynthia LevyDepartment of Medicine, Division of Digestive Health and Liver Diseases, University of Miami Miller School of Medicine, Miami, Florida, USA.
Eric F MartinDepartment of Medicine, Division of Digestive Health and Liver Diseases, University of Miami Miller School of Medicine, Miami, Florida, USA.
Aparna GoelDivision of Gastroenterology & Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
Mai SedkiDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Irena JankowskaHepato-Biliary-Pancreatic Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
Toru IkegamiDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Maria RodriguezEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Martina SterneckEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Marcial SebodeEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Christoph SchrammEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Maria Francesca DonatoEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Francesca ColapietroDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Ansgar LohseEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Raul J AndradeGastroenterology Service-IBIMA, University Hospital and CIBERehd, University of Málaga, Málaga, Spain.
Vilas R PatwardhanBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Bart van HoekLeiden University Medical Center, Leiden, The Netherlands.
Maaike BiewengaLeiden University Medical Center, Leiden, The Netherlands.
Andreas E KremerEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Yoshihide UedaDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Mark DeneauUniversity of Utah and Intermountain Healthcare Primary Children's Hospital, Salt Lake City, Utah, USA.
Mark PedersenThe University of Texas Southwestern Medical Center, Dallas, TX, USA.
Marlyn J MayoThe University of Texas Southwestern Medical Center, Dallas, TX, USA.
Annarosa FloreaniEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Patrizia BurraEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Maria Francesca SecchiEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Benedetta Terziroli Beretta-PiccoliEpatocentro Ticino & Università della Svizzera Italiana, Lugano, Switzerland.
Marco SciveresUPMC Pediatric Liver Center, Palermo, Italy.
Giuseppe MaggioreEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Syed-Mohammed JafriHenry Ford Health System, Michigan, USA.
Dominique DebrayEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Muriel GirardEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Florence LacailleEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Michael HeneghanInstitute of Liver Studies, King's College Hospital NHS Foundation Trust, Denmark Hill, SE59RS, London, UK.
Andrew L MasonDivision of Gastroenterology and Liver Unit, University of Alberta, Edmonton, AB, Canada.
Ye OoEuropean Reference Network for Hepatological Diseases (ERN RARE-LIVER).
Aldo J Montano-LozaDivision of Gastroenterology and Liver Unit, University of Alberta, Edmonton, AB, Canada.

Funding

TRAINING GRANT IN ACADEMIC GASTROENTEROLOGYT32DK007056 · NIDDK · STANFORD UNIVERSITY · PI Natalie J. Torok · 1986 to 2026
$6.5M
NIDDK NIH HHS T32 DK007056
6 · The paper itself

Abstract

Background & Aims: A significant proportion of patients with variant syndromes (VSs), namely autoimmune hepatitis/primary biliary cholangitis or autoimmune hepatitis/primary sclerosing cholangitis, require liver transplantation (LT) despite treatment. The frequency of disease recurrence and the effect on graft survival are yet to be clarified. The aim of this international, multicentric, retrospective study is to evaluate the risk factors associated with recurrence and the impact of the disease recurrence after LT on graft and patient survival. Methods: We evaluated 166 patients undergoing LT for VS in 33 centers in North America, South America, Europe, and Asia. Clinical data before and after LT, biochemical data within the first 12 months after LT, and immunosuppression after LT were analyzed to identify patients with a higher risk of recurrence of autoimmune disease based on a histological and radiological diagnosis. Cumulative probabilities of graft and overall survival after LT were calculated using a semi-Markov model. Results: The autoimmune pattern of recurrence resembled the original VS in 19 cases (61%). Recurrence of autoimmune liver disease ( Conclusions: Impact and implications: This study investigated the recurrence of autoimmune liver diseases (rALD) in patients transplanted for variant syndromes (VSs) and its effect on graft and patient survival. The findings reveal a significant association between

Indexed as

AutoimmunityLiver transplantationRecurrence

Identifiers

PMID40276483
PMCPMC12018556

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.