ArticleCase reports in infectious diseases2025
Febrile Pancytopenia and Hemophagocytosis From Disseminated Histoplasmosis in HIV/AIDS Patients: Two Cases and a Review of Combined Antifungal and Steroid Therapy.
Article in Case reports in infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Cytopenias With HIV in the Era of Highly Active Antiretroviral Therapy: Are We Winning the Battle?Health science reports · 2026Article
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4 authors.
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Abstract
Hemophagocytosis is a clinical condition characterized by the engulfment of bone marrow cellular elements, including erythrocytes, leukocytes, platelets, and their precursors, by activated macrophages. It has been associated with several infectious organisms, including the Epstein-Barr virus (EBV) and histoplasmosis. Human immunodeficiency virus (HIV) has been known to trigger hemophagocytosis in the presence or absence of other infections. Disseminated histoplasmosis is a common opportunistic infection in advanced patients with acquired immunodeficiency syndrome (AIDS) in endemic areas; however, the best treatment for histoplasmosis associated with hemophagocytosis is uncertain. This article presents two cases of patients with AIDS secondary to uncontrolled HIV who were admitted with fever, malaise, low CD4 + counts, and a history of noncompliance with antiretroviral therapy (ART). Both patients had pancytopenia, markedly elevated serum ferritin, and elevated liver transaminases. The diagnosis of histoplasmosis was confirmed by positive fungal blood cultures, buffy coat smears showing intracellular fungal organisms, and positive urine
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