ReviewCureus2025
Exploring Fatigue in Parkinson's Disease: A Comprehensive Literature Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Reliability and convergent validity of the 6-minute pegboard and ring test in people with Parkinson's disease: a cross-sectional study.Acta neurologica Belgica · 2026Article
- Review
- Epidemiology of autonomic dysfunction in Parkinson's disease (Review).Medicine internationalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatigue is one of the most prevalent and debilitating non-motor symptoms of Parkinson's disease (PD), affecting up to two-thirds of patients and significantly impacting quality of life. This review provides a comprehensive analysis of its complex pathophysiology, prevalence, clinical presentation, assessment methods, and current management strategies. Fatigue in PD is linked to dysfunction in dopaminergic and non-dopaminergic pathways, neuroinflammation, genetic predispositions, and metabolic dysregulation. Reported prevalence rates range from 36% to 60%, highlighting the need for standardized assessment tools and a universally accepted definition. Clinically, fatigue is characterized by an overwhelming and abnormal sense of exhaustion, often preceding motor symptoms by years. Distinguishing it from sleepiness, apathy, and depression is crucial for accurate diagnosis and treatment. Assessment primarily relies on patient-reported scales, such as the Fatigue Severity Scale and the Parkinson's Disease Fatigue Scale. Management includes both pharmacological and non-pharmacological approaches, with medications like methylphenidate and rasagiline showing potential, alongside physical exercise, cognitive behavioral therapy, and sleep disorder management. Further research is essential to unravel the underlying mechanisms, identify objective biomarkers, and develop more effective, targeted treatments for this burdensome symptom.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.