Evidence map›Paper›PMID 40276376›Full record

ReviewNeuro-oncology advances

Consortium for Intracranial Metastasis Academic Research (CIMARa): Global interdisciplinary collaborations to improve outcomes of patient with brain metastases.

Carey K Anders, Amanda E D Van Swearingen, Josh Neman, Johanna A Joyce, Diana M Cittelly, Manuel Valiente, Alexandra S Zimmer, Scott R Floyd, Ajay Dhakal, Soma Sengupta and 12 more

Erratum issuedAbstract readReview
In one paragraph

Review in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Metabolic adaptations of brain metastasis.Nature reviews. Cancer · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Carey K AndersDuke Center for Brain and Spine Metastasis, Duke Cancer Institute, Durham, North Carolina, USA.
Amanda E D Van SwearingenDuke Center for Brain and Spine Metastasis, Duke Cancer Institute, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0002-4287-9741
Josh NemanUniversity of Southern California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-6337-9615
Johanna A JoyceUniversity of Lausanne, Ludwig Institute for Cancer Research, Lausanne, Switzerland.
Diana M CittellyUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID https://orcid.org/0000-0002-8392-0800
Manuel ValienteBrain Metastasis Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.ORCID https://orcid.org/0000-0002-0647-7542
Alexandra S ZimmerOregon Health State University, Portland, Oregon, USA.
Scott R FloydDepartment of Radiation Oncology, Duke University, Durham, North Carolina, USA.
Ajay DhakalDepartment of Medicine, University of Rochester, Rochester, New York, USA.
Soma SenguptaDepartment of Neurology & Neurosurgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Manmeet S AhluwaliaMiami Cancer Institute, Miami, Florida, USA.
Seema NagpalDivision of Neuro-oncology, Stanford University, Palo Alto, California, USA.ORCID https://orcid.org/0000-0002-0289-2319
Priya U KumthekarNorthwester Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0001-5923-0677
Sam EmersonNeurological Surgery, University of Washington, Seattle, Washington, USA.
Reva BashoEllison Medical Institute, Los Angeles, California, USA.
Kathryn BealWeill Cornell Medicine, New York, New York, USA.
Nelson S MossMemorial Sloan Kettering Cancer Center, New York City, New York, USA.
Evangelia D RazisHygeia Hospital, Athens, Greece.
Jonathan T YangNew York University, New York City, New York, USA.
Sarah L SammonsDana Farber Cancer Institute, Boston, Massachusetts, USA.
Solmaz SahebjamJohns Hopkins School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0001-9930-9937
Hussein A TawbiAndrew M. McDougall Brain Metastasis Clinic and Research Program, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID https://orcid.org/0000-0003-1942-851X

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
A consortium effort to translate therapies for neurological diseases via an ex vivo organotypic platformU01TR003715 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BALDWIN, ALBERT SIDNEY, FLORES, CATHERINE T · 2021 to 2024
$4.6M
Novel Targets for Stroke Intervention - Gene Discovery for Modulators of InfarctionR01NS100866 · NINDS · DUKE UNIVERSITY · PI FLOYD, SCOTT R, MARCHUK, DOUGLAS A. · 2018 to 2022
$3.2M
Mechanisms of endocrine therapy and radiation synergism to decrease brain metastasesR01CA290813 · NCI · UNIVERSITY OF COLORADO DENVER · PI Diana M. Cittelly · 2024 to 2026
$2.7M
Mechanisms underlying pro-metastatic effects of estrogen in the brain nicheR37CA227984 · NCI · UNIVERSITY OF COLORADO DENVER · PI CITTELLY, DIANA M. · 2018 to 2024
$2.5M
BMX-001 as a Therapeutic Agent for Treatment of Multiple Brain Metastases.R44CA228694 · NCI · BIOMIMETIX JV, LLC · PI SILBERSTEIN, DAVID S. · 2018 to 2022
$2.3M
Development of MESH1 inhibitors to treat ferroptosis-associated neurodegenerationR21AG077075 · NIA · DUKE UNIVERSITY · PI CHI, JEN-TSAN ASHLEY, HONG, JIYONG · 2022 to 2022
$428k
NCATS NIH HHS U01 TR003715NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA290813NCI NIH HHS R37 CA227984NCI NIH HHS R44 CA228694NIA NIH HHS R21 AG077075NINDS NIH HHS R01 NS100866
6 · The paper itself

Abstract

Brain metastases (BrM) arising from solid tumors is an ever-increasing and often devastating clinical challenge impacting hundreds of thousands of patients annually worldwide. As systemic anticancer therapies, and thus survival, improve, the risk for central nervous system (CNS) recurrence has increased. Historically, patients with BrM were excluded from clinical trials; however, there has been a shift toward increasing inclusion over the past decade. To most effectively design the next generation of clinical trials for patients with BrM, a multidisciplinary team spanning local and systemic therapies is imperative. CIMARa (Consortium for Intracranial Metastasis Academic Research), formalized in June 2021, is an inclusive group of multidisciplinary clinical investigators, research scientists, and advocates who share the collective goal of improving outcomes for patients with BrM. CIMARa aims to improve outcomes through the development, coordination, and awareness of multi-institutional clinical trials testing novel therapeutic agents for this unique patient population alongside the translation of preclinical research to the clinical setting.

Indexed as

brain metastasescentral nervous system metastasesclinical trialsconsortiumresearch

Identifiers

PMID40276376
PMCPMC12019957

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.