Evidence map›Paper›PMID 40276330›Full record

ArticleFrontiers in allergy2025

A randomized controlled trial evaluating prophylactic treatment of

Le Cui, Na Gao, Cairong Bai, Yali Zuo, Wendong Hao, Kai Guan

Abstract read
In one paragraph

Article in Frontiers in allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Le Cui *Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Na Gao *Department of Allergy, The First Affiliated Hospital of Xi'an Jiaotong University, Yulin Hospital, Yulin, China.
Cairong BaiDepartment of Allergy, The First Affiliated Hospital of Xi'an Jiaotong University, Yulin Hospital, Yulin, China.
Yali ZuoDepartment of Allergy, The First Affiliated Hospital of Xi'an Jiaotong University, Yulin Hospital, Yulin, China.
Wendong HaoDepartment of Allergy, The First Affiliated Hospital of Xi'an Jiaotong University, Yulin Hospital, Yulin, China.
Kai GuanDepartment of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Prophylactic treatment for pollinosis is advantageous for managing nasal symptoms in patients with seasonal allergic rhinitis. Inadequate control of rhinitis symptoms increases the risk of acute asthma attacks. Nevertheless, there is limited research on the use of nasal glucocorticoids and antihistamines for the preventive treatment of pollinosis. Objective: This study aimed to assess the efficacy of prophylactic treatment for nasal symptoms and acute asthma attacks by enrolling patients with Methods: The study was registered at Chictr.org.cn (ChiCTR2300073758). A total of 120 patients with Results: During both the pollen season and the concurrent medication period, the prophylactic treatment group presented significantly lower total nasal symptom scores (TNSS) (means of 5.97 and 5.94) than the control group (means of 7.86 and 7.80) ( Conclusions: Prophylactic treatment with azelastine hydrochloride and fluticasone propionate nasal sprays can alleviate nasal symptoms and may reduce acute asthma attacks during the pollen season. Clinical Trial Registration: [Chictr.org.cn], identifier (ChiCTR2300073758).

Indexed as

allergic rhinitisArtemisiaasthmapollinosisprophylactic treatmentrandomized controlled trial

Identifiers

PMID40276330
PMCPMC12018361

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.