Evidence map›Paper›PMID 40276285›Full record

ArticleIDCases2025

A rare case of acute liver failure due to disseminated Varicella-Zoster Virus (VZV) infection.

Harris T Feldman, Matthew Neale, Ajay Batra, Mark Mangano, Michael C Newstein

Erratum issuedAbstract readCase Reports
In one paragraph

Article in IDCases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Harris T FeldmanUniversity of Massachusetts T.H. Chan Medical School, Worcester, MA, USA.
Matthew NealeUniversity of Massachusetts T.H. Chan Medical School, Worcester, MA, USA.
Ajay BatraUniversity of Massachusetts T.H. Chan Medical School, Worcester, MA, USA.
Mark ManganoUniversity of Massachusetts T.H. Chan Medical School, Worcester, MA, USA.
Michael C NewsteinUniversity of Massachusetts T.H. Chan Medical School, Worcester, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Varicella zoster virus (VZV) is a human alpha herpes virus that typically manifests in humans with two distinct cutaneous phenotypes: primary varicella, or chickenpox, and secondary reactivation, or Shingles, after establishing latency in the cranial and dorsal root ganglia. VZV infection can present with rarer manifestations including encephalitis, pneumonia, hepatitis, myocarditis, and nephritis. Immunocompromised populations are at the greatest risk for cutaneous and visceral dissemination. The progression of VZV hepatitis to acute liver failure is exceedingly rare, with very few published cases in the literature. In the following case, we report the initial presentation and clinical manifestations of an immunocompromised patient who presented with vesicular skin findings and elevated transaminases, who quickly progressed to acute liver failure, and had postmortem findings of disseminated VZV infection.

Indexed as

HepatitisImmunocompromisedLiver failureVaricella zoster virus (VZV)

Identifiers

PMID40276285
PMCPMC12020892

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.