SynthesisFrontiers in microbiology2025
Clinical efficacy of probiotic supplementation in the treatment of knee osteoarthritis: a meta-analysis.
Synthesis in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of probiotic supplementation on diabetic kidney disease: a systematic review and meta-analysis of randomized controlled trials.Frontiers in microbiology · 2026Pooled it
- Effectiveness and safety of probiotics in treating knee osteoarthritis: an updated systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2026Pooled it
- Randomized, Double-Blind, Placebo-Controlled Trial of ID-CBT5101, a TyndallizedJournal of microbiology and biotechnology · 2026Trial
- Probiotics improve functional performance in patients with osteoarthritis: a randomized placebo-controlled clinical trial.European journal of nutrition · 2025Trial
- Immune dysregulation in osteoarthritis: Mechanisms, biomarkers, and therapeutic opportunities.Journal of translational autoimmunity · 2026Review
- Gut and Joint Microbiome and Dysbiosis: A New Perspective on the Pathogenesis and Treatment of Osteoarthritis.Pathogens (Basel, Switzerland) · 2026Review
- Gut microbiota-immune crosstalk in osteoarthritis: pathogenic mechanisms and emerging therapeutic opportunities.Frontiers in microbiology · 2026Review
- Gut microbiota and osteoarthritis: mechanisms and translation.Frontiers in immunology · 2026Review
- Recent Developments in Osteoarthritis Research: Innovative Therapeutic Approaches and the Role of Polyphenols and Nanotechnology.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: We aimed to systematically evaluate and analyze the clinical efficacy of oral probiotics in the treatment of knee osteoarthritis (KOA) based on the theory of "gut-joint axis." Methods: We searched PubMed, The Cochrane Library, Embase, China Knowledge Network (CNKI), Wanfang Database, and Wipro Database (CQVIP) databases for clinical randomized controlled trials of oral probiotics for the treatment of KOA. The literature was organized by Note express software, and the quality of the included literature was evaluated according to the Cochrane systematic evaluation method, and meta-analysis was performed using RevMan 5.4 software. Results: Five randomized controlled trials with 694 participants were included in this study, and the results of the meta-analysis showed that the observation group experienced significant reductions in the Western Ontario and McMaster Universities Osteoarthritis Index total score, visual analog score, and high-sensitivity C-reactive protein level compared to the control group, but did not show significant differences in improvement of stiffness and regulation of body weight. Conclusion: Oral probiotics had an ameliorative effect on function, pain, and inflammatory response in patients with KOA, but our results need to be validated in future large-scale studies. Systematic review registration: The website is https://www.crd.york.ac.uk/PROSPERO/.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.