Evidence map›Paper›PMID 40276150›Full record

ArticleAdvanced synthesis & catalysis2025

Selectivity Rules for the Dearomative (3+2) Annulation Reaction Between Substituted Indoles and Oxyallyl Cations.

Dhiman Saha, Jimmy Wu

Abstract read
In one paragraph

Article in Advanced synthesis & catalysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Dhiman SahaDepartment of Chemistry, Dartmouth College, 41 College St., Hanover, NH 03755, USA.
Jimmy WuDepartment of Chemistry, Dartmouth College, 41 College St., Hanover, NH 03755, USA.

Funding

Novel Dearomative Indole Annulation Reactions, Beckmann Fragmentations, and Their Applications to SynthesisR01GM147650 · NIGMS · DARTMOUTH COLLEGE · PI WU, JIMMY · 2022 to 2025
$1.5M
NIGMS NIH HHS R01 GM147650
6 · The paper itself

Abstract

We report a collection of "selectivity rules" for the dearomative (3+2) annulation reaction between substituted indoles and oxyallyl cations. The application of these rules enables us to synthesize four different regioisomeric permutations of the annulation products in a stereoselective fashion. We demonstrated that these products could be further transformed into hexahydro- and tetrahydrocarbazoles by nucleophile-intercepted Beckmann fragmentation (NuBFr) and Beckmann fragmentation (BFr).

Indexed as

carbazoleindoleoxyallyl cationregioselectivestereoselective

Identifiers

PMID40276150
PMCPMC12017456

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.