ArticleComputational and structural biotechnology journal2025
Easy triplex: An online tool for predicting the formation of DNA-RNA triple helices.
Article in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing evidence supports the idea that intranuclear noncoding RNAs interact with target DNA to regulate their expression. The structural basis of this process involves the formation of DNA-RNA triple helices without unwinding the DNA double helix. This triplex formation process relies on the base pairing of the triplex target site (TTS) and the triplex-forming oligonucleotide (TFO), making the prediction of their binding crucial for mechanistic investigations. Here, we propose an online tool called Easy Triplex for predicting the formation of DNA-RNA triplexes. Using the canonical Hoogsteen pairing rules, Easy Triplex matches and predicts the details and distribution of all TTSs and TFOs on the basis of the user-provided DNA and RNA sequences. Practical application has shown that Easy Triplex can efficiently and accurately predict known triplex information. Its flexible parameter settings and scientifically set default output thresholds make Easy Triplex suitable for predicting the TFOs of both long and short noncoding RNAs. Additionally, users can choose to export the distribution information of CpG islands on the DNA sequence for further TTS screening. Thus, Easy Triplex is a simple and convenient online tool for predicting triplex formation. Easy Triplex is publicly accessible at http://easy-triplex.com/.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.