ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Examining the association between sleep apnea and total hippocampal volumes in cognitive impairment.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Exercise capacity of patients with obstructive sleep apnea at moderate to high altitude.Sleep & breathing = Schlaf & Atmung · 2026Article
- Clinical value of structural cranial magnetic resonance imaging analysis in assessing brain aging in ischemic stroke patients.BMC neurology · 2026Article
- Altered Cerebellar Spontaneous Activity and Its Association with Arousal Index in Comorbid Insomnia and Obstructive Sleep Apnea: A Resting-State fMRI Study.Journal of clinical medicine · 2026Article
- Waking up to the truth: Associations between sleep disorders and multidomain functional outcomes in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Acute normobaric hypoxia as a reversible probe of oxygen-limitation contributions to cognitive aging.Aging brain · 2026Review
- Associations Between Obstructive Sleep Apnea, Macro-Scale Glymphatic Coupling, and Episodic Memory Impairment in Middle-Aged and Older Adults.Nature and science of sleep · 2026Article
- Response letter: Examining the association between sleep apnea and total hippocampal volumes in cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Comment on "Examining the association between sleep apnea and total hippocampal volumes in cognitive impairment".Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Examining the association between sleep apnea and total hippocampal volumes in cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
introductionThe prevalence of dementia is rising due to an aging population. Given the known risks of obstructive sleep apnea (OSA) on cerebrovascular health, we hypothesized that markers of OSA would correlate with reduced hippocampal volumes in individuals with cognitive impairment due to neurodegenerative, vascular, or mixed (NVM) etiologies.
methodsData from 166 patients were retrospectively analyzed. Participants underwent polysomnography or home sleep apnea tests, alongside structural brain magnetic resonance imaging (MRI). They were categorized into cognitive impairment due to NVM etiology or subjective cognitive complaints. Multiple linear regression models examined correlations between sleep variables and hippocampal volume.
resultsThe presence of OSA, time under 90% oxygen saturation, and mean SpO DISCUSSION: These findings suggest that individuals with cognitive impairment due to NVM etiology experience underlying neurodegenerative processes, which increase susceptibility to the adverse effects of OSA. HIGHLIGHTS: Hypoxic burden, rather than AHI, was associated with hippocampal volume loss. The presence of OSA, T90%, and mean SpO
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