ArticleInfluenza and other respiratory viruses2025
The Role of Viral Interference in Shaping RSV Epidemics Following the 2009 H1N1 Influenza Pandemic.
Article in Influenza and other respiratory viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- Spatiotemporal Dynamics of Human Metapneumovirus and Potential Impact of Respiratory Syncytial Virus Interventions in the United States.medRxiv : the preprint server for health sciences · 2026Article
- Generalized fractional modeling and optimal control of respiratory syncytial virus infections in Florida.Scientific reports · 2026Article
- Impact of the COVID-19 Pandemic on Vaccine-Preventable Diseases in Mexico: A Time Series Analysis (2014-2024).Epidemiologia (Basel, Switzerland) · 2026Article
- The effect of non-pharmaceutical interventions on influenza throughout the COVID-19 pandemic: an 8-year interrupted time series study.Scientific reports · 2026Article
- Association between seasonal respiratory virus activity and invasive pneumococcal disease in central Ontario, Canada.BMC infectious diseases · 2026Article
- Shifts in seasonal timing of respiratory diseases and causes of death following a natural pandemic event.PLOS global public health · 2026Article
- Post-Pandemic Dynamics of the Global Circulation of Human Metapneumovirus and Respiratory Syncytial Virus.The Journal of infectious diseases · 2025Article
- Influenza A virus interferes with respiratory syncytial virus in mice and reconstituted human airway epithelium.Microbiology spectrum · 2025Article
- Construction and validation of a predictive model for severe pneumonia risk using respiratory pathogen nucleic acid Ct values combined with host immune biomarkers.American journal of translational research · 2025Article
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Abstract
backgroundDisruptions in respiratory syncytial virus (RSV) activity were observed in different countries following the 2009 influenza pandemic. Given the limited use of non-pharmaceutical interventions, these disruptions provide an opportunity to probe viral interference due to the out-of-season epidemics. The objectives of the study are twofold: to characterize atypical RSV activity in the United States (US) and to explore the mechanisms underlying changes in RSV epidemics following the pandemic.
methodsLaboratory-confirmed RSV cases across 10 US regions from June 2007 to July 2019 were analyzed. A dynamic time warping method was used to characterize RSV activity in different seasons. A two-pathogen model was constructed to explore viral interference mechanisms. A sampling-importance-resampling method was applied to estimate the effects of viral interference.
resultsWe found that RSV activity was reduced following the influenza pandemic in the 2009/10 season across all regions in the US. By contrast, we found an enhanced but delayed RSV epidemic across the US in the 2010/11 season. Using a mathematical model, we explored three potential viral interference mechanisms that could explain the change of RSV activity following the pandemic. The pandemic influenza may interfere with RSV to reduce susceptibility to RSV coinfection, or shorten the RSV infectious period, or decrease RSV infectivity in co-infections.
conclusionsThis study provides statistical evidence for atypical RSV seasons following the influenza pandemic in the US and sheds light on viral interference mechanisms affecting RSV epidemics, offering a model-fitting framework for analyzing surveillance data at the population level.
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