Evidence map›Paper›PMID 40275713›Full record

ArticleJournal of dental research2025

Splicing Defects and Cell Death Cause

S Rao, K E N Watt, L Maili, M Lamb, E Farrow, H Hassan, K Weaver, B Miller, S Dash, L L Cox and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

S RaoDepartment of Oral and Craniofacial Sciences, University of Missouri-Kansas City, Kansas City, MO, USA.
K E N WattDepartment of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
L MailiStowers Institute for Medical Research, Kansas City, MO, USA.
M LambStowers Institute for Medical Research, Kansas City, MO, USA.
E FarrowChildren's Mercy Hospital, Kansas City, MO, USA.
H HassanStowers Institute for Medical Research, Kansas City, MO, USA.
K WeaverStowers Institute for Medical Research, Kansas City, MO, USA.ORCID 0000-0002-3960-9177
B MillerStowers Institute for Medical Research, Kansas City, MO, USA.
S DashStowers Institute for Medical Research, Kansas City, MO, USA.
L L CoxDepartment of Oral and Craniofacial Sciences, University of Missouri-Kansas City, Kansas City, MO, USA.
L GallacherVictorian Clinical Genetics Services, Murdoch Children's Research Institute, Parkville, Australia.
S G KantDepartment of Clinical Genetics, Erasmus University Medical Center, Rotterdam, Netherlands.
M GibsonChildren's Mercy Hospital, Kansas City, MO, USA.
T PastinenChildren's Mercy Hospital, Kansas City, MO, USA.
D LiThe Children's Hospital of Philadelphia, Philadelphia, PA, USA.
E J K BhojThe Children's Hospital of Philadelphia, Philadelphia, PA, USA.
H ZhuSchool of Engineering Medicine, Beihang University, Beijing, China.
J ZhangPlastic Surgery Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Y-B ZhangSchool of Engineering Medicine, Beihang University, Beijing, China.
T Y TanVictorian Clinical Genetics Services, Murdoch Children's Research Institute, Parkville, Australia.
P A TrainorStowers Institute for Medical Research, Kansas City, MO, USA.ORCID 0000-0003-2774-3624
T C CoxDepartment of Oral and Craniofacial Sciences, University of Missouri-Kansas City, Kansas City, MO, USA.ORCID 0000-0001-8015-5528

Funding

The role of rRNA transcription and ribosome biogenesis in neural crest progenitors and stem cells during embryonic and postnatal craniofacial developmentF32DE033617 · NIDCR · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI Lorena Maili · 2023 to 2026
$239k
Functional Characterization of Mediator Complex Proteins in Neural Crest and Craniofacial DevelopmentK99DE030972 · NIDCR · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI DASH, SOMA · 2022 to 2023
$200k
NIDCR NIH HHS F32 DE033617NIDCR NIH HHS K99 DE030972
6 · The paper itself

Abstract

Craniofacial microsomia (CFM) is a genetically and phenotypically heterogeneous disorder characterized by hypoplasia of facial tissue that is often asymmetric. Affected tissues typically include the ears (external and internal), mandible, and maxilla, but various extracranial anomalies have also been reported. Loss-of-function variants in the

Indexed as

Goldenhar SyndromePhosphoproteinsRNA SplicingRNA Splicing FactorsAnimalsApoptosisCell DeathCell ProliferationFemaleHumansLoss of Function MutationMaleNeural CrestPedigreePhenotypeTumor Suppressor Protein p53PhosphoproteinsRNA Splicing FactorsTumor Suppressor Protein p53Zebrafish Proteinscartilagecohort studiescraniofacial anomaliescraniofacial biology/geneticsdevelopmental biologygenomics

Identifiers

PMID40275713
PMCPMC12491969

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.