Observational studyEuropean journal of neurology2025
Predictors of Recovering Full Consciousness: Results From a Prospective Multisite Italian Study.
Observational study in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04495192 (Clinical, Neurophysiological and Genetical Predictors of Consciousness Recovery and Functional Outcomes After Severe Acquired Brain Injuries), which is not on this map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical, Neurophysiological and Genetical Predictors of Consciousness Recovery and Functional Outcomes After Severe Acquired Brain Injuries
Who cites it
4 citing papers in PubMed.
- EEG functional connectivity measures for differentiating 6-month consciousness-related outcome after brain injury.BMC medical imaging · 2026Article
- Disorders of consciousness diagnosis, interventions, and prognostication for the intensivist: Report of the 2025 ISICEM roundtable.Intensive care medicine · 2026Review
- Neurophysiological predictors of full clinical consciousness recovery in patients with DoC: a retrospective evaluation of the DoC-NP Score.Frontiers in neurologyArticle
- Prognosis and recovery trajectories in prolonged disorders of consciousness: protocol for the PDOCC 5-year prospective cohort study.Frontiers in neurologyArticle
Corrections and comments
- Erratum issued
Authors and funding
20 authors.
Funding
Abstract
backgroundImproving prognostication in patients with a prolonged disorder of consciousness (pDoC) is among the most challenging issues in neurorehabilitation. The aim of this Italian multisite prospective longitudinal study was to identify valuable predictors of the complete recovery of consciousness (emergence from Minimally Conscious State, eMCS) at 3 months (T1) from the admission in intensive rehabilitation units (IRUs) in pDoC (T0).
methodsPatients with Unresponsive Wakefulness Syndrome (UWS) or MCS admitted within 3 months of injury to 4 Italian IRUs were included. Demographic, clinical, and neurophysiological data were collected at T0, and a clinical diagnosis of consciousness (UWS, MCS-, MCS+) was established at T0 and T1 using the Coma Recovery Scale-Revised (CRS-R).
resultsOne hundred forty-three patients were initially included and 131 completed follow-ups at T1: (76 males; median age: 69 years [IQR = 23]; VS/UWS: 51, MCS-: 29, MCS+: 51; etiology: 33 traumatic, 14 anoxic, 24 ischemic, 55 hemorrhagic, 5 other; median time post-injury: 40 days [IQR = 23]). At T1, 77 patients were eMCS, and 10 improved their clinical diagnosis. Among the clinical and neurophysiological independent variables, a higher CRS-R visual sub-score and the presence of EEG reactivity to eye opening at T0 were the best independent predictors of eMCS. Out of 77 eMCS, 18 reached a moderate disability (Glasgow Outcome Scale Extended-GOSE > 4), while the others persisted with a severe disability (GOS-E ≤ 4).
conclusionsA multimodal assessment can help identify patients who achieve functionally relevant improvements and thus better support clinicians when communicating with caregivers.
trial registrationClinicalTrials.gov registration number: NCT04495192.
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